The aims of the present study were to determine whether exposure to high peaks of ozone resulted in an increased prevalence of asthma or respiratory symptoms among bleachery workers and whether nitric oxide (NO) was elevated in the exhaled air of these workers. Bleachery workers (n=228) from three Swedish pulp mills who had been exposed to ozone, together with 63 unexposed control subjects, wer...

Objective: To review the fast-developing topic of assessment of exhaled breath components to improve the diagnosis and monitoring of respiratory and systemic diseases. Data Sources: Review of the literature available in monographs and journals. Study Selection: Articles and overviews on the broad spectrum of existing experimental and routinely applied methods to assess different aspects of huma...

STUDY OBJECTIVES Inducible nitric oxide synthase (iNOS) is upregulated in a number of inflammatory lung conditions, and exhaled nitric oxide (NO) concentration is increased. However, previous studies in children with cystic fibrosis (CF) have shown that exhaled NO is reduced. The purpose of this investigation was to study exhaled NO concentration in adults with CF, and to investigate the effect...

Endogenously produced nitric oxide is a recognized regulator of physiological lung events, such as a neurotransmitter and a proinflammatory mediator. We tested the differences between chronic and acute nitric oxide inhibition by N(omega)-nitro-L-arginine methyl ester (L-NAME) treatment in lung mechanics, inflammation, and airway remodeling in an experimental asthma model in guinea pigs. Both ac...

Multiple flow rates of exhaled nitric oxide (eNO) fraction (F(e,NO)) data can be modelled to estimate airway wall concentration of nitric oxide (C(aw,NO)), diffusing capacity of nitric oxide (D(aw,NO)), alveolar nitric oxide concentration (C(alv,NO)) and total maximal flux of nitric oxide in the airway compartment (J'(aw,NO)). F(e,NO) at 10, 30, 50, 100 and 200 mL.s(-1) from 50 chronic obstruct...

*Dept of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London, UK. **Dept of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden. Correspondence. P.J. Barnes, Dept of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK. Received: April 3 1997; accepted for publication April 25 1997 This document was prepared follo...