p18(INK4c) is a member of the INK4 family of proteins that regulate the G(1) to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6. The p16(INK4a) member of the INK4 protein family is altered in a variety of cancers and structure-function studies of the INK4 proteins reveal that the vast majority of missense tumor-derived p16(INK4a) ...

Background & objectives: The Integrated Health System (SIB) is the latest electronic health record system in Iran, officially began in Iran in March 2016, with the goal of integrating health information and providing health services. This study aimed to design a model for establishment of the electronic health record in family physician program of Guilan university of medical sciences. Method:...

p18 is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclindependent kinases 4 and 6. The p16 member of the INK4 protein family is altered in a variety of cancers and structure-function studies of the INK4 proteins reveal that the vast majority of missense tumor-derived p16 mutations reduce protein...

CONTEXT The Centers for Medicare & Medicaid Services have elected to include a bereaved family member survey in public reporting of hospice quality data as mandated in the Affordable Care Act. However, it is not known what time point after death offers the most reliable responses. OBJECTIVES To examine the stability of bereaved family members' survey responses when administered three, six, an...

We introduce a new family of explicit integrators for stiff Itô stochastic differential equations (SDEs) of weak order two. These numerical methods belong to the class of onestep stabilized methods with extended stability domains and do not suffer from stepsize reduction that standard explicit methods face. The family is based on the classical stabilized methods of order two for deterministic p...

A family of time-varying hyperbolic systems of balance laws is considered. The partial differential equations of this family can be stabilized by selecting suitable boundary conditions. For the stabilized systems, the classical technique of construction of Lyapunov functions provides a function which is a weak Lyapunov function in some cases, but is not in others. We transform this function thr...

We show a simple method for constructing an infinite family of graph formation games with link bias so that the resulting games admits, as a pairwise stable solution, a graph with an arbitrarily specified degree distribution. Pairwise stability is used as the equilibrium condition over the more commonly used Nash equilibrium to prevent the occurrence of ill-behaved equilibrium strategies that d...

We introduce the concepts of Grover operators and Grover kernels to systematically analyse Grover’s searching algorithms. Then, we investigate a one-parameter family of quantum searching algorithms of Grover’s type and we show that the standard Grover’s algorithm is a distinguished member of this family. We show that all the algorithms of this class solve the searching problem with an efficienc...

We introduce a new family of explicit integrators for stiff Itô stochastic differential equations (SDEs) of weak order two. These numerical methods belong to the class of one-step stabilized methods with extended stability domains and do not suffer from the stepsize reduction faced by standard explicit methods. The family is based on the standard second order orthogonal Runge-Kutta Chebyshev me...