The diagnosis of follicular dendritic cell (FDC) sarcoma can be challenging because of its morphologic overlaps with many other spindle cell neoplasms and, therefore, new phenotypic markers will be helpful in its differential diagnosis. Podoplanin is a mucin-type transmembrane glycoprotein that has recently been detected in reactive FDCs. In this study, we investigated the expression patterns o...

To explore the biologic significance of the membrane-anchored form of macrophage colony-stimulating factor (M-CSF), we examined whether interaction between membrane-bound M-CSF and its receptor mediates intercellular adhesion as well as cell proliferation and differentiation. Human M-CSF receptors were expressed on a murine interleukin-2 (IL-3)-dependent cell line, FDC-P2, by DNA transfection w...

Natural sheep scrapie is a prion disease characterized by the accumulation of PrP(Sc) in brain and lymphoid tissues. Previous studies suggested that lymph node macrophages and follicular dendritic cells (FDC) accumulate PrP(Sc). In this study, lymph nodes were analyzed for the presence of PrP(Sc) and macrophage or FDC markers using dual immunohistochemistry. A monoclonal antibody (mAb) to the C...

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular dilatation and impaired systolic function. Patients with DCM suffer from heart failure, arrhythmia, and are at risk of premature death. DCM has a prevalence of one case out of 2500 individuals with an incidence of 7/100,000/year (but may be under diagnosed). In many cases the disease is inherited and is termed f...

PURPOSE To uncover the signaling pathways underlying follicular lymphoma-follicular dendritic cells (FL-FDC) cross-talk and its validation as new targets for therapy. EXPERIMENTAL DESIGN FL primary cells and cell lines were cocultured in the presence or absence of FDC. After 24 and 48 hours, RNA was isolated from FL cells and subjected to gene expression profiling (GEP) and data meta-analysis...

This paper presents a new nonlinear backstepping controller for a direct-driven permanent magnet synchronous generator-based wind turbine, which is connected to the power system via back-to-back converters. The proposed controller deals with maximum power point tracking (MPPT) in normal condition and enhances the low-voltage ride-through (LVRT) capability in fault conditions. In this method, to...

-In the micro-grid, droop control strategy simulates traditional power system droop characteristics , by changing the output of active and reactive power to control the output voltage frequency and amplitude, thus the micro-grid system can work at the stabilize voltage point in island operation mode . And the voltage is more or less with the grid-connect mode,so that the transition is smooth wh...

this paper undertakes the synthesis of a logic-based switching h2/h∞ state-feedback controller for continuous-time lti singular perturbation systems. our solution achieves a minimum bound on the h2 performance level, while also satisfying the h∞ performance requirements. the proposed hybrid control scheme is based on a fuzzy supervisor managing the combination of two controllers. a convex lmi-b...

BACKGROUND The prescription of fixed-dose combinations (FDC) of antihypertensive drugs has increased rapidly since the relaxation of the prescription-term restriction. In this study, we used the opportunity of this policy change in Japan as an instrument to assess the causal impact of switching to FDC on hypertensive treatment costs. METHODS Claims data from 64 community pharmacies located in...

A rare case of follicular dendritic cell (FDC) sarcoma is reported. A 71-year-old woman was admitted for evaluation of constipation. Computerized tomography showed cervical, supraclavicular, retroperitoneal, and paraaortic lymphadenopathies. Histological findings from a cervical lymph node revealed Hodgkin's disease at first. But tumors that arose both in the cervical and the left interscapular...