BACKGROUND Pre-existing polyps, especially large polyps, are known to be the major source for colorectal cancer, but there is limited available information about factors that are associated with polyp size and polyp growth. We aim to determine factors associated with polyp size in different age groups. METHODS Colonoscopy data were prospectively collected from 67 adult gastrointestinal practi...

Heat treatment is a simple technique for releasing polyphosphate (polyP) from microbial cells. We investigated the ultrastructural alterations of polyP granules (PPGs) in response to heat treatment at 70 degrees C using a polyP-accumulating phoU mutant of Escherichia coli as a model organism. Electron microscopic and energy-dispersive X-ray analysis suggested concurrent occurrence of PPG degrad...

A 65−year−old man was referred to our de− partment for polypectomy. A polyp, 20 mm in diameter, was found in the as− cending colon on colonoscopy (Figure1 a). The polyp surface was covered by charac− teristic multiple dimples, long thin ves− sels, and mucus. Chromoendoscopy with 0.4% indigo carmine enhanced the ap− pearance of the polyp surface dimples, and subsequent magnification revealed a t...

Background: Vocal abuse and misuse would result in vocal fold polyp. Certain features define the extent of vocal folds polyp effects on voice acoustic parameters. The present study aimed to define the effects of polyp size on acoustic voice parameters, and compare these parameters in hemorrhagic and non-hemorrhagic polyps.Methods: In the present retrospective study, 28 individuals with hemorrha...

Polyphosphate kinase (PPK), the principal enzyme required for the synthesis of inorganic polyphosphate (polyP) from ATP, also exhibits other enzymatic activities, which differ significantly in their biochemical optima and responses to chemical agents. These several activities include: polyP synthesis (forward reaction), nATP --> polyP(n) + nADP (Equation 1); ATP synthesis from polyP (reverse re...

Recently two approaches were reported that addressed a vitally important problem in regenerative medicine, i. e. the successful treatment of wounds even under diabetic conditions. Accordingly, these studies with diabetic rabbits [Sarojini et al. PLoS One 2017, 12(4):e0174899] and diabetic mice [Müller et al. Polymers 2017, 9, 300] identified a novel (potential) target for the acceleration of wo...

Inorganic polyphosphates (polyp) are naturally occurring linear polymers of orthophosphate that are found in microorganisms, lower eukaryotes such as yeast, and animals (Harold 1966, Kulaev and Vagabov 1983; Wood and Clark 1988). In certain cases, polyp can accumulate to more than 10% of total dry mass. The ubiquitous presence of polyp suggests that they may have important physiological functio...

A 47 year old female with papillary thyroid carcinoma was referred to our department for post-treatment whole body iodine scanning. The acquired images revealed a focal zone of intense radiotracer uptake in the right lower quadrant of the abdomen. SPECT/CT fused slices showed a focal zone of the radioiodine (131I) uptake in the right colon wall. Colonoscopy revealed a pedunculated po...

Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that activated platelets release inorganic polyphosphate (polyP), a polymer of 60-100 phosphate residues that directly bound to and activated the plasma protease factor XII. PolyP-driven factor XII activation triggered release of the inflammatory mediator bradykinin by plasma kallikrein-mediated kininogen process...