Manufacturing systems, where the materials which are handled are mainly composed of discrete entities, for example parts that are machined and/or assembled, are called discrete manufacturing systems. The rapid development of industrial techniques makes the manufacturing systems larger and more complex, in which system control is divided into a hierarchy of control levels: planning, scheduling, ...

In the sheet metal industry, companies rely on nesting procedures to organise cut patterns of metal. Most current algorithms and methods focus solely laying out cutting only reduce material usage. However, in dynamic manufacturing environments, such as engineer order (ETO) companies, efficient has be addressed together with effective production scheduling. Therefore, reducing trade-off between ...

Implementing a highly flexible manufacturing approach, like mass customization manufacturing, demands an integrated design and simulation system. This system must be able to cope with difficult issues such as a high level of product variety, uncertainty in the product demand forecast, and the reconfiguration of manufacturing resources to support the introduction and integration of new manufactu...

This paper presents the idea of creating cells while reducing part-level sequence-dependent setup time in general cellular manufacturing systems (CMS). Setup time reduction in CMS has gained modest attention in the literature. This could be attributed to the fact that the fundamental problem in cell formation in CMS has been mainly related to material handling and machine utilization while setu...

in this study, our aim was to produce a generation of gmp-grade adipose tissue-derived mesenchymal stem cells for clinical applications. according to our results, we fulfill to establish consistent and also reproducible current good manufacturing practice (cgmp) compliant adipose tissue-derived mesenchymal stem cells from five female donors. the isolated cells were cultured in dmem supplemented...