Introducción: la deficiencia congénita del factor V (FVD) es un trastorno hemorrágico raro causado por mutaciones en el gen FV que reduce cuantitativamente los niveles plasmáticos de FV, cuya incidencia estimada 1 1.000.000 población general y se hereda con patrón autosómico recesivo. La enfermedad clínicamente heterogénea; las complicaciones potencialmente mortales como hemorragias sistema ner...

This paper is devoted to the presentation and analysis of some linear and quadratic finite volume (FV) schemes for elliptic problems with singular solutions due to the non-smoothness of the domain. Our FV schemes are constructed over specially-designed graded triangular meshes. We provide sharp parameter selection criteria for the graded mesh, such that both the linear and quadratic FV schemes ...

Let Fv and Fe be sets of faulty vertices and faulty edges, respectively, in the folded hypercube FQn so that |Fv| + |Fe| ≤ n − 2, for n ≥ 2. Choose any fault-free edge e. If n ≥ 3 then there is a fault-free cycle of length l in FQn containing e, for every even l ranging from 4 to 2 − 2|Fv |; if n ≥ 2 is even then there is a fault-free cycle of length l in FQn containing e, for every odd l rangi...

To investigate the molecular mechanisms of the quantitative factor V (FV) deficiency associated with the FV R2 haplotype, 4 missense mutations, Met385Thr, His1299Arg, Met1736Val, and Asp2194Gly, identified in the R2 haplotype allele, were analyzed by in vitro expression studies. The FV variant carrying all 4 mutations showed a markedly lower steady-state expression level than wild-type FV becau...

En esta investigación se evaluo el efecto de la combinación fibra vidrio y aditivo sikacem PE, cuya procedencia son las botellas que obtuvo en almacenes marca, los cuales van a ser incorporados mezcla del concreto con objetivo alterar su resistencia compresión flexión como objetivos primer nivel segundo nivel, es verificar trabajabilidad asentamiento concreto. La dosificación fue reemplazada re...

Background and Aims: Congenital factor V (FV) deficiency is a rare bleeding disorder with 1 in 1000000 persons in the general population. Individuals with FV activity <1% and very low FV antigen levels are characterized as severe FV deficient patients. Little data is available about the molecular basis of this bleeding disorder in Iran. Materials and Methods: We analyzed 7 unrelated Iranian FV...

Friend leukemia virus (FV) suppressed the proliferative responses of spleen, lymph node, marrow, and thymus cell populations to various T- and B-cell mitogens. Cells taken from mice, e.g. BALB/c genetically susceptible to leukemogenesis in vivo were much more susceptible to suppression of mitogenesis in vitro than similar cells from genetically resistant mice, e.g., C57BL/6. Nylon wool-purified...

Understanding the host genetics of the immune response in retrovirus infection models could provide insights for basic HIV vaccine discovery. In Friend retrovirus (FV) infection of mice, Fv1 differentially inhibits N-tropic versus B-tropic FV infection by mediating a capsid-dependent post-entry block, Fv2 susceptibility governs splenomegaly induction, and Rfv3 resistance primes a stronger neutr...

The generation of thrombin by the prothrombinase complex constitutes an essential step in hemostasis, with thrombin being crucial for the amplification of blood coagulation, fibrin formation, and platelet activation. In the prothrombinase complex, the activated form of coagulation factor V (FVa) is an essential cofactor to the enzyme-activated factor X (FXa), FXa being virtually ineffective in ...

Two G-to-A mutations at positions 1691 of the factor V (FV) gene and 20210 of the prothrombin (FII) gene have been associated with an increased risk of venous thromboembolism. We report a thrombosis-prone family in which one subject--the propositus who exhibited combined heterozygous FV G1691A and FII G20210A mutations--showed spontaneous and early clinical onset (at 23 years), recurrences of d...