نتایج جستجو برای: genetic therapy
تعداد نتایج: 1239366 فیلتر نتایج به سال:
Objective(s) Despite the enormous heterogeneity of genetic hearing loss, most non-syndromic hearing losses are caused by mutations in the GJB2 gene. We aimed to characterize the mutation profiles of 100 Iranian deaf patients that were under 10 years old. Materials and Methods Patients were tested with direct sequencing of entire coding region of the GJB2 gene. Results Eight known mutations...
Down syndrome (DS) is a birth defect with huge medical and social costs, caused by trisomy of whole or part of chromosome 21. It is the most prevalent genetic disease worldwide and the common genetic cause of intellectual disabilities appearing in about 1 in 400-1500 newborns. Although the syndrome had been described thousands of years before, it was named after John Langdon Down who described ...
background and objectives: rapid, accurate and cost effective diagnosis of infectious and non infectious diseases is an essential step for treatment process. nowadays, in line with scientific progression in molecular biology, genetics and biochemistry which are based on biotechnology and genetic engineering aspects, new branch of medicine entitled molecular medicine is being derived. it can be ...
triple negative breast cancers (tnbcs) are associated with aggressive course, higher rates of visceral and central nervous system metastases and lower survival rate than hormone receptor positive. once metastasis has occurred, a median survival was approximately one year. currently, chemotherapy in tnbc is similar to other her2- negative breast cancers but in the near future, it will revolution...
BACKGROUND Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy. METHODS A community-based cohort study (the Malmo Diet and Ca...
The introduction of targeted therapies for the treatment BRAF-mutant melanomas have improved survival rates in a significant proportion patients. Nonetheless, emergence resistance to remains inevitable most Here, we review known and emerging molecular mechanisms that underlay development MAPK inhibition melanoma cells potential strategies overcome these mechanisms. Multiple genetic non-genetic ...
Breast cancer comprises a heterogeneous group of tumor subtypes, whether defined by immunohistochemistry key proteins, RNA expression profiles, or genetic alterations, and each these subtypes may benefit from distinct treatment approach. However, there can be striking heterogeneity within tumors, which pose challenges to the development personalized approaches therapy. Intratumor divided into t...
Background: Phenylketonuria is an inherited metabolic disease. It is genetic disorder autosomal recessive type. It is caused by absent or deficiency Phenylalanine hydroxylase enzyme activity that converts Phenylalanine to Tyrosine. It leads to increasing Phenylalanine in the blood. Tyrosine is important for production of some neurotransmitters. So it caused deficiencies of dopamine and serotoni...
Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy that uses the patient's immune system. It creates cancer-killing T cells through genetic modification targets tumor antigens. CAR consists three fundamental units, extracellular, transmembrane, and intracellular domains. CARs are rapidly evolving with progress in field starting from first-generation to next-generation CAR...
Background: Apoptin is a protein from chicken anemia virus that could induce apoptosis specifically in the cancer cells but it has not any effect in the normal cells. Phage therapy is a novel field of cancer therapy and phage nanobioparticles (NBPs) such as λ phage could be modified to deliver and express genetic cassettes into eukaryotic cells safely in contrast with animal viruses. The bacter...
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