Background: Aminoglycosides, particularly gentamicin, endure crucial antibiotics in the armamentarium for severe Gram-negative bacterial infections through their significant risk nephrotoxicity. Co-administration of several applicant nephroprotective agents has been investigated at preclinical level. Garlic was proved to be an oxidative stress combatant with unique antioxidant potential.Aim wor...

Most investigations of the comparative nephrotoxicities of aminoglycosides in animals have utilized large multiples of the human dose. Furthermore, many of these assessments have used only one or two dose levels and have not described a dose-response comparison among antibiotics. Because of this lack of comparative dose-response data over a range of low multiples of the human dose, the nephroto...

Therapeutic effect of ethanolic extract of Hygrophila spinosa in gentamicin-induced nephrotoxic model of kidney injury in male Sprague-Dawley rats was studied. Rats were administered with gentamicin at a dose of 80 mg/kg intraperitoneally (ip) to induce nephrotoxicity. Kidney function was assessed by measuring serum creatinine and urea. Kidney superoxide dismutase, lipid peroxidation, catalase ...

INTRODUCTION The nephroprotective effect of the aqueous extract of Costus afer leaves was evaluated in male albino Wistar rats with gentamicin-induced kidney injury. MATERIALS AND METHODS In a 2-phase study, 30 weight-matched male Albino Wistar rats were divided into 6 groups of 5 animals to receive gentamicin, 90 mg/kg/d (except for the control group) for 7 days in the first phase to induce ...

Increased production of reactive oxygen species (ROS) may be a common pathway in atherosclerosis, diabetes, cataract, accelerated ageing, and drug toxicities. The protective role of N-acetyl cysteine (NAC) and magnesium (Mg) in gentamicin induced nephrotoxicity was evaluated . One hundred albino rats were divided into 5 groups. Sham control group (A), Gentamicin group (B), Gentamicin + NAC grou...

Purpose: To investigate the reno-protective properties of Cinnamomum tamala against gentamicininduced nephrotoxicity in rabbits. Methods: Rabbits were randomly divided into four groups (n = 6) including Group-1 (normal saline), Group-2 (gentamicin, 80 mg/kg/day), Group-3 (C. tamala, 200 mg/kg/day) and Group-4 (gentamicin, 80 mg/kg/day and C. tamala, 200 mg/kg/day). Body weight, blood urea nitro...

A study was conducted to evaluate the protective effect of aqueous seed extract of Carica papaya L. on gentamicin induced hepatotoxicity and nephrotoxicity in Wistar rats. A control group (Group I, n=12) was compared with rats administrated with 40 mg/kg gentamicin, once daily for 14 days (Groups II, III and IV, n=12 each). The effect of aqueous extract of Carica papaya L. at a dose level of 20...

To assess their potential value as early indicators of gentamicin-induced kidney damage, lysosomal hydrolases were measured in the 24-h urines of rats receiving 30 or 60 mg of gentamicin per kg per day for 15 days. Proteinuria, urine osmolality, blood urea nitrogen, and creatinine clearance were also measured. Kidney tissue was examined by both light and electron microscopy. Beta-galactosidase,...

The present study aimed to evaluate the nephroprotective effects of different doses of aqueous extract of olive leaf (OLE), vitamin E and their combination on gentamicin induced nephrotoxicity in albino rats. 54 adult healthy male rats were divided into nine groups comprising 6 animals each. Group 1 served as normal control group. All other groups (group 2 to group 9) were administered gentamic...