نتایج جستجو برای: gentamicin nephrotoxicity

تعداد نتایج: 14285  

Journal: :Journal of nephropathology 2012
Majid Tavafi

Gentamicin nephrotoxicity limit its usage against gram negative bacteria. Most researches showed that antioxidant agents improved gentamicin nephrotoxicity. According to these investigations oxidative stress play a central role in the mechanism of gentamicin induced nephrotoxicity. Recently Rafieian-Kopaei and colleagues showed that erythropoietin significantly ameliorated serum creatinine, blo...

Journal: :iranian journal of veterinary research 2007
a. derakhshanfar a. bidadkosh s. kazeminia

the specificity of gentamicin for vitamin e deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. to determine the ways in which vitamin e manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...

Journal: :iranian journal of basic medical sciences 0
zeynab mohamadi yarijani medical biology research center, kermanshah university of medical sciences, kermanshah, iran houshang najafi medical biology research center, kermanshah university of medical sciences, kermanshah, iran seyed hamid madani department of pathology, school of medicine, kermanshah university of medical sciences, kermanshah, iran

objective(s): gentamicin is used for the treatment of gram-negative bacterial infections. however, gentamicin administration is limited because of nephrotoxicity. the aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. materials and methods: thirty two male wistar rats received gentamicin (100 mg/kg, ip), with or without cr...

Journal: :iranian journal of veterinary research 2009
a. derakhshanfar a. bidadkosh m. hashempour sadeghian

the clinical uses of gentamicin have so far been restricted due to nephrotoxicity and ototoxicity. the exact mechanism of nephrotoxicity is still unknown; however, it appears that free radicals may be involved. methionine has previously been shown to alleviate oxidative stress involved in ototoxicity due to its antioxidant properties. therefore, the effect of methionine supplementation on the g...

Journal: :international journal of advanced biological and biomedical research 2014
nahid alaeyan jahromi majid alaeyan jahromi sedigheh tanomand ali reza alaeyan jahromi houshang jamali

background and methodology: gentamicin is a broad-spectrum antibiotic with restricted application in man and stock due to its side effects such as nephrotoxicity and autotoxicity. cinnamon bark has antioxidant properties. this is the first study on the protective effects of the hydroalcoholic extract of cinnamon on gentamicin-induced nephrotoxicity.methods and materials: thirty-six mature femal...

Journal: :international journal of advanced biological and biomedical research 2014
sedigheh tanomand nahid alaeyan jahromi zahra alaeyan jahromi houshang jamali majid alaeyan jahromi

background and purpose: gentamicin-induced nephrotoxicity results from the production of reactive oxygen species (ros) in the kidneys, and since cinnamon has antioxidant properties, this research studied the effects of cinnamon extract on the prevention and treatment of gentamicin-induced toxicity in immature white rats.materials and methodology: in this study 36 immature female wistar rats wer...

2015
Yanina Dubrovskaya Rainer Tejada Joseph Bosco Anna Stachel Donald Chen Melinda Feng Andrew Rosenberg Michael Phillips

BACKGROUND Recent studies described an increase in acute kidney injury when high dose gentamicin was included in perioperative prophylaxis for orthopedic surgeries. To this effect, we compared the rate of nephrotoxicity for selected orthopedic surgeries where gentamicin was included (Gentamicin Group) to those where it was not included (Control Group) for perioperative prophylaxis and evaluated...

Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against bacterial. However, gentamicin can induce nephrotoxicity. In this research, hydroalcoholic extract of Rheum turkestanicum was used against gentamicin- induced nephrotoxicity. Rheum turkestanicum is used aga...

Journal: :international journal of preventive medicine 0
ardeshir talebi amirhossein karimi khadija ouguerram nasrin vahidi-ataabadi fatemeh eshraghi-jazi azam mansouri

background: gentamicin (gm) is used as antibiotic for gram-negative infections, but its administration is limited due to a side-effect of nephrotoxicity. it was attempted to investigate the effect of althaea officinalis flower extract (aofe) against nephrotoxicity induced by gm in male rats. methods: 30-year-old male wistar rats were divided into five groups. group 1 as a negative control group...

Journal: :Antimicrobial agents and chemotherapy 1979
R Bloch F C Luft L I Rankin R S Sloan M N Yum D R Maxwell

In rats, cephalothin exerts a protective effect upon the nephrotoxicity of gentamicin. To examine the possibility that this effect is also observed with carbenicillin, we gave the following (milligrams per kilogram) to rats daily for 14 days: gentamicin alone, 60; gentamicin plus cephalothin, 100, 500, or 1,000; gentamicin plus carbenicillin, 50, 100, 250, 500, or 1,000. A 500-mg/kg dose of cep...

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