OBJECTIVE To determine the effectiveness of acute-phase pharmacological and psychological treatments of depression in older ambulatory patients by systematically reviewing original research relevant to this topic. METHODS Searches in MEDLINE and PsycINFO and manual reviews of bibliographies located 233 articles. Of these, 40 (37 different studies) met our 8 inclusion criteria: original resear...

OBJECTIVE Gender differences in antidepressant treatment response, side effects, dropout rates, and plasma concentrations were examined in patients with major and predominantly melancholic depression. METHOD The study included a subgroup of 292 inpatients (96 men, 196 women) from three Danish double-blind, randomized, controlled trials. All patients completed a 5-week treatment period and ful...

BACKGROUND It remains unclear whether or not a positive family history of affective disorders predicts the effectiveness of antidepressant treatment of depression. AIMS Assess the relationship of a family history of affective disorders to the efficacy of duloxetine in the treatment of depressive disorder. METHODS Seventy-seven patients with depressive disorder (as defined by the 10th editio...

objective: depression is a major health problem, which is not only underrecognized and undertreated, but is also associated with significant morbidity and mortality. it has been suggested that combination therapy rapidly reduces depressive symptoms in patients with moderate to severe depression and is more effective than monotherapy; but this suggestion remains controversial. serotonergic and n...

Thirty patients of primary depression were assessed for their cognitive functions initially in the depressed state and on complete recovery. The results indicate presence of definite cognitive impairment during the depressed state (as measured by the Bhatia's Battery test and PGI memory scale) which is restored to normal after recovery from depression. The intensity of depression as indicated b...

The daily electronic self-monitoring Smartphone software "MONARCA" was used by 17 patients with bipolar disorder for 3 consecutive months. Patients were rated fortnightly using Hamilton Depression rating Scale 17 items (HDRS-17) and Young Mania rating Scale (YMRS) (102 ratings) with blinding for Smartphone data. Objective Smartphone measures such as physical and social activity correlated with ...

OBJECTIVE The aim of this study is to explore the resting-state functional connectivity (FC) differences between the paired default mode network (DMN) subregions in patients with primary insomnia (PIs). METHODS Forty-two PIs and forty-two age- and sex-matched good sleepers (GSs) were recruited. All subjects underwent the resting-state functional magnetic resonance imaging scans. The seed-base...

The emergence of depression in the course of schizophrenia is common and arouses much interest and therapeutic concern. It has been associated with a less favorable prognosis and increased incidence of suicide. However, relatively few treatment studies have been performed in this area. The use of a combination of antidepressants and antipsychotic agents is controversial. We report an open-label...