نتایج جستجو برای: heat shock protein 70
تعداد نتایج: 1639345 فیلتر نتایج به سال:
introduction: the aim of this study was to investigate the effect of the hsp-70 (heat shock protein-70) induction in the lysate of heat shocked tumor cells on splenocyte proliferation, nitric oxide production by peritoneal macrophages, and fibrosarcoma tumor size reduction in balb/c mice. material and methods: wehi 164 cells (mouse fibrosarcoma cell line) were injected subcutaneously into the r...
Nanovaccines based on superparamagnetic iron oxide nanoparticles (SPIONs) provide a novel approach to induce the humoral and cell-based immune system to fight cancer. Herein, we increased the immunostimulatory capacity of SPIONs by coating them with recombinant heat shock protein 70 (Hsp70) which is known to chaperone antigenic peptides. After binding, Hsp70-SPIONs deliver immunogenic peptides ...
Induced thermotolerance in murine embryos occurs at the 8-cell stage when embryos are maintained in vitro but not until the blastocyst stage if development proceeds in vivo. Present results indicate that ability of embryos to undergo induced thermotolerance is not limited by heat shock protein 70 (HSP70) synthesis. Exposure of 8-cell embryos to 40 degrees C enhanced synthesis of 2 constitutive ...
Glucocorticoids are the most important mediator of muscle cachexia in various catabolic conditions. Recent studies suggest that the transcription factor NF-kappaB acts as a suppressor of genes in the ubiquitin-proteasome proteolytic pathway and that glucocorticoids increase muscle proteolysis by downregulating NF-kappaB activity. The heat shock (stress) response, characterized by the induction ...
Xenopus cells express two major proteins on heat shock, designated hsp 70 and hsp 30. Several cDNA clones for the corresponding mRNAs were identified and sequenced. Inducibility and abundance of heat shock mRNAs in various cell types and developmental stages was determined by nuclease S1-mapping. The only cells found to contain hsp 70 mRNA without heat shock are the oocytes. The level of this s...
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