The classification of autoimmune hemolytic anemias and the complement system are reviewed. In autoimmune hemolytic anemia of the warm antibody type, complement-mediated cell lysis is clinically relevant in a proportion of the patients but is hardly essential for hemolysis in most patients. Cold antibody-mediated autoimmune hemolytic anemias (primary cold agglutinin disease, secondary cold agglu...

OBJECTIVES To present a case of acute brucellosis triggering acute hemolytic anemia in a subject with glucose-6-phosphate dehydrogenase (G6PD) deficiency. CLINICAL PRESENTATION AND INTERVENTION A 17-year-old male patient presented with fever, malaise and jaundice. His blood and bone marrow cultures yielded Brucella species. In addition, he was found to have acute hemolytic anemia due to previ...

Rationale Atypical hemolytic uremic syndrome, which has a high probability of chronic kidney disease, morbidity, and mortality, needs to be promptly recognized when patients present with microangiopathic hemolysis. Presenting Concerns of the Patient Three patients present with laboratory parameters consistent with a thrombotic microangiopathy. With a suspected diagnosis of thrombotic thromboc...

When a reaction occurs during or after the transfusion of a blood product, those involved in the care of that patient tend to think first of an immunological evenł. l However, many transfusion reactions may not be immunologically mediated. The differential diagnosis of a transfusion reaction should include the many nonimmune conditions that can lead to the destruction of either donor or recipie...

BACKGRUND Hemolytic uremic syndrome is a disease characterized by hemolytic anemia, thrombocytopenia and acute renal failure with multiple organ involvement. Central nervous system involvement is detected in 20-50% of the patients and this leads to increased morbidity and mortality. CASE REPORT We report the neuroimaging findings in a four-month-old male with hemolytic uremic syndrome. The ce...

Covalently closed circular deoxyribonucleic acid (DNA) molecules were isolated by cesium chloride centrifugation in the presence of ethidium bromide from a naturally occurring beta-hemolytic Escherichia coli strain (SC52). The open circular forms have contour lengths of 2.25 +/- 0.1 mum, 24.0 +/- 0.3 mum, and 29.5 +/- 0.5 mum. The beta-hemolytic character of E. coli SC52 can be transferred by c...

INTRODUCTION Studies on the carriage rate of beta-hemolytic streptococci among children form an important component of public health practice to prevent disease complications such as rheumatic fever/rheumatic heart disease, nephritis, and other local or systemic infections. METHODOLOGY Throat swabs collected from asymptomatic schoolchildren were inoculated into appropriate media for isolation...

Group B beta-hemolytic streptococci were isolated from the throats of 49 of 1,110 patients who had pharyngitis. Compared with patients whose throat cultures were negative for beta-hemolytic streptococci, those harboring group B were more likely to have enlarged tonsils (P less than 0.001), exudate (P less than 0.02), and tender enlarged anterior cervical lymph nodes (P less than 0.01). Group B ...

1. Thirteen strains of hemolytic streptococci isolated from patients with acute rheumatic fever did not show any evidence of being related serologically. 2. Strains of hemolytic streptococci exist which, although identical by the agglutination test, do not show complete reciprocal agglutinin absorption. Sera prepared from such related strains may show some protective power in mice against anoth...

Sclera from donor globes was eluted in phosphate-buffered saline at 4 degrees C for 24 hr. Hemolytic assays were used to measure functional C1, C4, C2, C3, C5 and C6 in scleral eluates. Radial immunodiffusion was used to measure Factor B, a component of the alternative complement pathway, and albumin in scleral eluates. Molecular weight appeared to be a factor in determining the hemolytic activ...