ABSTRACT Hereditary hemochromatosis (HH) is an autosomal recessive disease, most often associated with mutations in the HFE gene, which result continuous absorption of iron, causing its overload. Liver tissue main site iron deposition; thus, high levels when interacting oxygen, induce formation free radicals that will act on proteins, lipids, and deoxyribonucleic acid (DNA), may trigger deleter...

Ivan L. Angulo1 Dimas T. Covas2 Antonio A. Carneiro3 Oswaldo Baffa4 Jorge Elias Junior5 Guilherme Vilela6 Accumulation of iron in thalassemia causes organ damage and reduces patient survival due to heart lesions in the second decade of life. Iron deposits are monitored by direct (biopsy) and indirect methods (ferritin) with sequential data being better than isolated measurements. This paper com...

Hereditary aceruloplasminemia is a rare disease characterized by iron overload and neurodegeneration. Aceruloplasminemia is due to the absence/deficiency of ceruloplasmin, responsible for iron overload in liver, pancreas and other organs. We report the case of an Italian patient with hyperferritinemia, diabetes and hepatic iron excess, suspected to be affected by aceruloplasminemia. Patient und...

Magnetic resonance imaging (MRI) is a well-established imaging modality to evaluate increased iron deposition in the liver. Both standard liver imaging series with in-phase and out-of-phase T1-weighted sequences for visual detection, as well as advanced T2- and T2*-weighted measurements may be used for mapping the iron concentration. In this article, we describe different forms of liver iron ac...

Magnetic resonance imaging (MRI) has been considered for the quantification of iron overload in liver. Iron was found to correlate with T2* measurement using weighted images. In this work, we address problem estimation liver MRI. We propose a general framework all models proposed literature. The task is then formulated as minimization problem, and suitable regularization functions are assigned ...

1. A high proportion of the ferritin in normal serum binds to concanavalin A. Binding is prevented by the addition of alpha-D-methylglucoside to the reaction mixture. 2. Ferritin in extracts of normal heart, liver and spleen or serum ferritin from patients with massive hepatic necrosis does not bind to concanavalin A. 3. Isoelectric focusing of preparations of serum ferritin from patients with ...