The liver metabolizes lidocaine by oxidative deethylation to form monoethylglycinexylidide (MEGX), an analyte proposed as an index of liver function. We determined MEGX and lidocaine serum concentrations with the TDx (Abbott Laboratories) at baseline and 15, 30, 60, and 90 min after the intravenous administration of lidocaine (1 mg/kg), analyzing specimens from 12 apparently healthy volunteers ...

Researchers who work on hepatitis may sometimes think that they have come to a dead end with non-A, non-B hepatitis, but in recent years there has been gradual progress in knowledge about these diseases. A hepatitis A like agent that causes epidemic waterborne non-A, non-B hepatitis has been characterized, and the epidemiology of the different forms of non-A, non-B hepatitis has been clarified....

Chronic hepatitis B is the most important cause of liver cirrhosis in Asia. Liver fibrosis is the intermediate stage to liver cirrhosis. Determining severity of liver fibrosis is important to determine the prognosis, risk of hepatocellular carcinoma, and need for antiviral therapy. Liver biopsy is the gold standard, but it is limited by its invasiveness and risk of bleeding. Transient elastogra...

background hepatic fibrosis is an inclusion indicator for treatment and a major independent predictor of treatment response in patients with chronic hepatitis c. liver biopsy, considered as the “gold standard” for evaluating liver fibrosis, has carried some drawbacks. currently used noninvasive predictors of fibrosis are considered less accurate than liver biopsy. objectives our aim was to asse...

Introduction and Aim: Kyrgyzstan is one of the most focused countries in WHO European Region for acute viral hepatitis. The objective this study to evaluate etiology, clinical laboratory characteristics, outcomes patients with Materials Methods: This a prospective conducted on 122 hepatitis at our hospital from March 2017 June 2020. diagnosis was based standard case definition: sudden onset sym...

BACKGROUND AND AIMS The importance of the hepatocyte ploidisation pattern to the control of cell proliferation and differentiation has been well established. However, there are no data that have characterised hepatocyte ploidy at various stages of chronic liver inflammation and fibrosis in vivo. METHODS We therefore investigated hepatocyte ploidy/binuclearity patterns in 57 patients with chro...

Hepatitis A (HAV) causes one of the most common infectious diseases in the world and may produce clinical conditions ranging from a-symptomatic infection to acute liver failure. Hepatitis A infection is an endemic problem in most African and South American Countries, meanwhile its incidence has largely declined over the last 2 decades in Western Europe and USA [1, 2]. The traditional preventive...

BACKGROUND Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. AIM To verify the usefulness of a new fibrosis index the globulin/platelet model in patients with chronic hepatitis B and to compare it wit...

BACKGROUND An estimated 1 million needlestick injuries (NSIs) occur in Europe each year. The Council Directive 2010/32/EU on the prevention of NSIs describes minimum requirements for prevention and calls for the implementation of local, national and Europe-wide reporting systems. The Directive is to be implemented by all EU member states by 11 May 2013. The purpose of this study was to assess (...

This study was performed to determine the risk of family members of anti-hepatitis C virus (HCV)-positive hemophilia patients (index patients) for infection with HCV compared with the risk of acquiring hepatitis B virus (HBV), human immunodeficiency virus (HIV), and hepatitis A virus (HAV) infection. All index patients (n = 141) were found to be positive by first and second generation anti-HCV ...