background: viral load and alanine aminotransferase (alt) levels may not be the key points for making a decision in the treatment of anti-hbe positive chronic hepatitis b. the purpose of this study was to assess the histological evaluation of liver to find the need for treatment on 72 patients with anti-hbe positive chronic hepatitis b. methods: the liver biopsy slides of the 72 patients (56 su...

background: the mean platelet volume (mpv) is the most commonly used measure of platelet size and is a potential marker of platelet reactivity. in this study, we aimed to explore the relationship between hepatic  histopathology in viral hepatitis and mpv levels,which are associated with platelet count and activity. materials and methods: we performed a retrospective case-control study of baseli...

BACKGROUND One of the major morphologic characteristics of hepatitis B is a hepatocellular regeneration which is induced by massive hepatocyte necrosis and associated with proliferative activity of hepatocytes. The purpose of this study is to document the proliferative activity of hepatocytes in various types of hepatitis B by immunohistochemical staining for proliferative cell nuclear antigen-...

BACKGROUND Hepatitis C recurring after orthotopic liver transplantation varies in severity and some patients rapidly develop fully established liver cirrhosis. Neither clinical nor biological markers of such rapid cirrhotic evolution are available. AIM To assess the value of histology in identifying patients who will develop cirrhosis shortly after liver transplantation. PATIENTS AND METHOD...

BACKGROUND/AIMS Hepatitis C virus leads to chronic liver disease, cirrhosis and hepatocellular cancer. Viral markers and other laboratory tests used in the diagnosis and follow-up of chronic hepatitis C do not correlate well with disease activity and liver histopathology. Therefore, alternative tests that indicate disease activity and relate with liver biopsy findings are needed. We aimed to in...

background: in patients with hepatitis b and c, environmental factors such as smoking and alcohol can cause liver fibrosis progression. but opium effects on liver fibrosis progression are not clear. this study was designed to assess the relationship of opium user and liver fibrosis progression. methods: in this case-control study, sixty patients in hepatitis b group and sixty patients in hepati...

aim : in the current study, we aimed at identifying independent laboratory parameter to predict liver damage. background : although liver biopsy is frequently recommended in assessing disease severity and selecting antiviral treatment candidates, it has several limitations. patients and methods : a total of 527 patients with untreated chronic hepatitis b virus infection were selected. a percuta...

BACKGROUND Chronic hepatitis C virus infection associated with contaminated anti-D immunoglobulin has become an issue of recent concern. The clinical course of chronic hepatitis C infection is unpredictable and histological assessment is felt to be the most reliable means of assessing disease status. Semiquantitative scoring systems have been devised, which assess degree of necroinflammatory di...