â  â  hepatocellular carcinoma (hcc) is a major worldwide public health concern. despite recent advances, there has been little success in improving the survival of hcc patients. due to advances in diagnostic modalities and the increasing incidence of chronic viral hepatitis and nonalcoholic fatty liver disease (nafld), both of which are well known risk factors of hcc, the prevalence of hcc is ...

conclusion the study data highlighted good value of iodine-based material decomposition images of spectral ct in assessment of both lipiodol deposition and residual cancer for follow-up of hcc patients previously treated with tace. background it is critical to follow up hepatocellular carcinoma (hcc) after transcatheter arterial chemoembolization (tace) in clinical practice. computed tomography...

context hepatocellular carcinoma (hcc) is a fatal disease. chronic hepatitis b virus (hbv) and/or hepatitis c virus (hcv) infection is the major cause of hcc. high viral replication rate and related hepatic/systematic inflammation are the major risk factors in hcc recurrence after hepatectomy or liver transplantation. evidence acquisition some of the carcinogenesis-related hbv mutations are als...

context since the introduction of highly active anti-retroviral regimen for human immunodeficiency virus-1 infection, a significant increase in the incidence of hepatocellular carcinoma has been reported in patients already chronically infected with hepatitis b virus and then given this form of regimen for their retroviral infection. evidence acquisition this phenomenon was initially attributed...

The article presents updated data concerning the molecular mechanisms of influence well-known in clinical practice drug Mastodynon. paper provides evidence a significant effect compounds containing its composition on cell lines number malignant neoplasms: breast cancer, hepatocellular carcinoma, leukemia and others. obtained are extremely attractive perspective using as preventive agent.

BACKGROUND F-box only protein 8 (FBX8), a novel component of F-box proteins, is lost in several cancers and has been associated with invasiveness of cancer cells. However, its expression pattern and role in the progression of hepatocellular carcinoma remain unclear. This study investigated the prognostic significance of FBX8 in hepatocellular carcinoma samples and analyzed FBX8 function in hepa...

PURPOSE Small molecule inhibitors of the mitogen-activated protein kinase (MAPK) pathway, such as sorafenib, represent novel treatment options for advanced hepatocellular carcinoma. The aim of our study was to identify downstream targets as biomarker candidates that are directly linked to the oncogenic MAPK pathway in hepatocellular carcinoma and correlate with inhibition of this pathway by mul...

Multitarget compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms of a particular combination of relatively more specific (i.e., ostensibly single target) compounds. We test this hypothesis for the geldanamycin ana...

Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and transforming growth factor-β1 (TGFβ1) has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomeras...