background: mycobacterium tuberculosis is the causative agent of tuberculosis (tb). bacille calmette-guerin (bcg) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult tb vaccine. the aim of this study was to develop a new tuberculosis dna vaccine candidate encoding a recombinant hspx-ppe44-esxv fusion antigen of m. tuberculosis. methods: a fu...

We describe a case of young adult female with Henoch-Schonlein purpura (HSP) presenting cutaneous and gastrointestinal manifestations. Biopsy revealed leukocytoclastic vasculitis in the skin. Steroid therapy led to initial resolution symptoms followed by relapse rashes subsequent introduction azathioprine. HSP is most common childhood uncommonly seen adults. Early recognition disease, especiall...

Henoch-Schönlein purpura (HSP), the most common type of leukocytoclastic vasculitis, is caused by T cell-mediated autoimmune reactions. In this study, we analyze histone modification patterns in peripheral blood mononuclear cells (PBMCs) of HSP patients, and investigate the expression levels of inflammatory cytokines (IFN-γ, IL-2, IL-4, IL-6 and IL-13), transcription factors (T-bet, GATA-3 and ...

Background: Shoulder pain is prominent among sedentary employees who make motions of the upper limbs on a regular basis. Rounded shoulder posture (RSP) and hunched (HSP) are most common clinical postural misalignments. These causes spine to bend raise tension nerve roots, which has negative impact upper-extremity muscular strength function. Therefore, this study was carried out investigate effe...

Suppressors of Cytokine Signaling (SOCS) family members are inhibitors of cytokine signaling pathways. Emerging evidence suggests the involvement of SOCS1 and SOCS3 in a variety of diseases, including allergy, autoimmune diseases, and inflammation. This study aimed to investigate the expression of SOCS1 and SOCS3 in the development of Henoch-Schoenlein Purpura (HSP) in children. Peripheral Bloo...

background: noradrenaline (na), the principal neurotransmitter released from sympathetic nerve terminals, influences t-cell maturation, not only directly in developing t cells, but also indirectly, by acting on the thymic nonlymphoid cells. in vitro and in vivo studies have demonstrated the anti-proliferative, anti-migratory, antiangiogenic and cytotoxic properties of propranolol, β-ar blocker,...

Endemann M, Bergmeister H, Bidmon B, Boehm M, Csaicsich D, Malaga-Dieguez L, Arbeiter K, Regele H, Herkner K, Aufricht C. Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis. Am J Physiol Renal Physiol 292: F47–F56, 2007; doi:10.1152/ajprenal.00503.2005.—Low biocompatibility of peritoneal dialysis fluid (PDF) injures mesothelia...

OBJECTIVE: Life-threatening conditions cause severe changes in the organization and conformation of macromolecules, creating urgent requirements for protein repair to ensure survival. As molecular chaperones, heat shock proteins (HSP) that have specialized functions in protein folding are now well established to restore homeostasis in cells and organisms. Augmentation of HSP synthesis is tightl...