Normal human glomerular basement membrane (H-GBM) was solubilized by collagenase and subjected to crossed immunoelectrophoresis with rabbit antibodies against H-GBM. Seven precipitates appeared with the mobility of alpha, beta, and gamma globulins. Only two of these precipitates might be specific for GBM, since the other precipitates disappeared after absorption of the antiserum with liver and ...

Neurotoxic esterase (NTE), the putative target for organophosphorus-induced delayed axonopathy, has been found in preparations of human placenta. The activity was primarily found in membrane-enriched fractions rather than high-speed supernatant. NTE was solubilized from a mixture of mitochondrial and microsomal membranes with Triton X-100. The crude and solubilized activities had inhibitor char...

BACKGROUND Human placenta is a convenient resource for biomedical research, and has not yet been used for neurointerventional surgery research. OBJECTIVE Our objective was to explore the feasibility of using human placenta to test various endovascular interventions and for training. DESIGN 18 placentas soon after delivery were prepared for six pilot studies. (1) Study on anatomical similari...

In all mammals including humans, development takes place within the protective environment of the maternal womb. Throughout gestation, nutrients and waste products are continuously exchanged between mother and fetus through the placenta. Despite the clear importance of the placenta to successful pregnancy and the health of both mother and offspring, relatively little is understood about the bio...

the objectives of this study were to 1) describe the risk factors, incidence, production and reproduction consequences of retained placenta in dairy cows, and 2) estimate the financial losses associated with retained placenta. calving records from march 2008 to december 2013 comprising 59,341 calving were included in the data set. the effects of risk factors on retained placenta incidence were ...

Despite its crucial role in the health of both the fetus and the pregnant woman, the placenta is the least understood human organ. Since a growing body of evidence also underscores the importance of placental development in the lifelong health of both mother and offspring, this lack of knowledge about placental structure and function is particularly concerning. Given modern approaches and techn...

The human placenta has long been the subject of scientific interest due to the important roles which it performs during pregnancy in sustaining the fetus and maintaining fetomaternal tolerance. More recently, however, researchers have begun to investigate the possibility that the placenta’s utility may extend beyond fetal development to act as a source of cells with clinically relevant properti...

conclusions tachyzoite of toxoplasma and dna of this parasite were observed in sub mucosa and muscles of the uterus and in the villis of placenta, but not in histological sections of the fetus. therefore, histological and molecular results were consistent. background toxoplasma gondii is an important zoonotic pathogen. vertical transmission of the parasite occurs when females were infected prim...

The system A amino acid transporter is encoded by three members of the Slc38 gene family giving rise to three subtypes: SNAT1, SNAT2, and SNAT4. SNAT2 is expressed ubiquitously in mammalian tissues, SNAT1 is predominantly expressed in heart, brain, and placenta while SNAT4 is reported to be expressed uniquely by the liver. In the placenta, system A has an essential role in the supply of neutral...

As a field of study, genomic imprinting has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and approximately 50 in the human. The imprinted expression of genes may be transient and highly tissue-specific, and there are potentially hundreds of other, as yet undiscovered, imprinted transcripts. The placenta is notable amongst mammalian o...