Insulin-like growth factor I (IGF-I) coordinates proliferation and differentiation in a wide variety of cell types. The igf1 gene not only produces IGF-I, but also generates multiple carboxy-terminal extensions, the E-peptides, through alternative splicing leading to different isoforms. It is not known if the IGF-I isoforms share a common pathway for their actions, or if there are specific acti...

Tüm memeli sütlerinde farklı miktarlarda bulunan insülin benzeri büyüme faktörü (IGF-1) yenidoğan için gen sinyalizasyon sisteminin başlıca düzenleyicisidir. Önemli bir anabolik hormon olan IGF-1’in temel biyolojik fonksiyonları hücre metabolizmasının düzenlenmesi, büyüme, çoğalması ve programlı ölümüdür. Serumdaki seviyesi ile insan sağlığı üzerine olumlu olumsuz etkilerini veya hastalık riskl...

Type 2 Diabetes Mellitus (Type DM) is a metabolic disorder group with mechanisms that include hyperglycemia, insulin resistance and hyperinsulinemia. DM has close association IGF-1, where the active form of IGF-1 becomes elevated by reason fact hyperinsulinemia inhibits production IGF-binding proteins (IGFBP) 1/IGFBP 2. The ability to promote cell proliferation inhibit apoptosis, hence one risk...

Acromegaly is a rare disease being followed up by primary care team. It usually caused pituitary adenoma and the treatment would be resection of tumour. But surgical intervention end for acromegalic patient? This case highlighted continuity in 65-year old gentleman who had been diagnosed acromegaly since age 31. He undergone transseptal transsphenoidal his when he was 45-year-old. Postoperative...

Molecular genetics selection on individual genes is a promising method to genetically improve economically important traits in livestock. The insulin like growth factor-I (IGF-I) gene may play important roles in growth of multiple tissues, including muscle cells, cartilage and bone. The objectives of the present study were the estimate the haplotype frequencies of the IGF-I gene polymorphisms i...

Although the effect of insulin-like growth factors (IGFs) in fetal adrenocortical cells has been investigated extensively, the role of the IGF system in the adult human adrenal gland remains unclear. In the present study we investigated the effect of recombinant human IGF-I and IGF-II on cortisol, dehydroepiandrosterone sulfate (DHEA-S) and cAMP synthesis in adult human adrenocortical cells in ...

Human alveolar macrophages, when activated, release a progression-type growth factor for fibroblasts that signals "competent" fibroblasts to replicate. The present study demonstrates that this growth activity is an insulin-like growth factor I (IGF-I)-type molecule. Partial purification of medium conditioned by activated alveolar macrophages using ion exchange and gel filtration chromatography ...

The type 1 insulin-like growth factor receptor (IGF1R) and its ligands (IGF-I and IGF-II) have been implicated inavarietyofphysiologicprocessesand indiseases suchas cancer. Inaddition to IGF1R, IGF-II alsoactivates the insulin receptor (IR) isoformA, and therefore, antibodies against IGF-II can inhibit cell proliferation mediated by the signaling through both IGF1R and IR triggered by IGF-II. W...

A variety of bone and soft-tissue sarcoma cell lines have been shown to express receptors for insulin-like growth factor-1 (IGF-1) and to respond mitogenically to IGF-1 in vitro. We have recently demonstrated evidence of IGF dependency in murine MGH-OGS and RIF-1 sarcomas, which express relatively high and intermediate levels of IGF-1 receptors. Overexpression of IGF-1 receptors and/or IGF liga...