BACKGROUND Interleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus. Its receptor, IL-31RA, is expressed by a number of cell types, including epithelial cells, eosinophils, and activated monocytes and macrophages. To date, however, the regulation of Th2 responses by distinct cel...

Localized aggressive periodontitis (LAgP) is a complex multifactorial periodontal disease to which genetic factors are thought to predispose individuals. Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are potent immunomodulators and proinflammatory cytokines that have been implicated in the pathogenesis of autoimmune and infectious diseases and proposed to be risk factors for ...

Psoriasis is characterized by a specific microRNA expression profile, distinct from that of healthy skin. MiR-31 is one of the most highly overexpressed microRNAs in psoriasis skin; however, its biological role in the disease has not been studied. In this study, we show that miR-31 is markedly overexpressed in psoriasis keratinocytes. Specific inhibition of miR-31 suppressed NF-kB–driven promot...

Epidermolysis bullosa (EB) is a hereditary disorder characterized by mechanical stress-induced blistering. The presence of extracutaneous complications such as cardiomyopathy and renal disease observed in severe EB subtypes the fact that pruritus common symptom across all indicate not only skin fragility but also systemic inflammatory disorder. Our study aims to elucidate basis inflammation see...

Background: Cerebral sinovenous thrombosis (CSVT) is a neurovascular disorder that occurs when a blood clot develops in a vein near the brain. Evaluating the subsequent changes in inflammatory cytokines can better reveal the underlying pathogeneses. Objective: To assess the serum levels of interleukin-10 (an anti-inflammatory cytokine) and IL-17 (a pro-inflammatory cytokine) in patients with as...

With ever-increasing pressure to conserve IP address space on the Internet, it makes sense to consider where relatively minor changes can be made to fielded practice to improve numbering efficiency. One such change, proposed by this document, is to halve the amount of address space assigned to point-to-point links (common throughout the Internet infrastructure) by allowing the use of 31-bit sub...

Abstract Objectives Epidermolysis bullosa (EB) is a hereditary disorder characterized by mechanical stress‐induced blistering. The presence of extracutaneous complications such as cardiomyopathy and renal disease observed in severe EB subtypes the fact that pruritus common symptom across all indicate not only skin fragility but also systemic inflammatory disorder. Our study aims to elucidate ba...