It is essential to use highly antigenic epitope areas, since the development of peptide vaccines heavily relies on precise design regions that can elicit a strong immune response. Choosing experimentally for production SARS-CoV-2 vaccine be time-consuming, costly, and labor-intensive. Scientists have created in silico prediction techniques based machine learning find these regions, cut down num...

Abstract The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to millions deaths, and devastated social, financial political entities around world. Without existing effective medical therapy, vaccines are urgently needed avoid this disease. In study, we propose in silico deep learning approach for prediction design a multi-epitope vaccine (DeepV...

Abstract No-cloning theorem forbids perfect cloning of an unknown quantum state. A universal machine (UQCM), capable producing two copies any input qubit with the optimal fidelity, is fundamental interest and has applications in information processing. This enabled by delicately tailored nonclassical correlations between copying qubits, which distinguish UQCM from a classical counterpart, but w...

Clubroot disease caused by Plasmodiophora brassicae is one of the major threats to Brassica crops. New clubroot resistant varieties Chinese cabbage (B. rapa ssp. pekinensis) have been developed through breeding, but underlying genetic mechanism resistance still unclear. In this study, two DH lines, clubroot-resistant Y635-10 and susceptible Y177-47 were crossed develop F2 population for fine ma...

Background: Tuberculosis (TB) remains as a major cause of death around the world. Construction of a new vaccine against tuberculosis is an effective way to control it. Several vaccines against this disease have been developed. The aim of the present study was to cloning of tb10.4 gene in pcDNA3.1+ plasmid and evaluation of its expression in eukaryotic cells. ...

An increasing number of studies have demonstrated the effectiveness of flagellin (FliC) as an adjuvant. In this study, FliC(s) from Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa, and Escherichia coli were compared. In silico studies were designed to determine physicochemical parameters of FliC from different bacteria. The fliC gene corresponding to best model was amplified, cl...

in recent years, the cloning technology has remarkably developed iran, but unfortunately, the required legal framework has not been created to support and protect such developments yet. this legal gap may lead to abuse of scientific researches to obtain illegal benefits and to undermine the intellectual property rights of scientists and researchers. thus to prevent such consequences, the attemp...