Oncogenes are often dysregulated in B cell tumors as a result of a reciprocal translocation involving an immunoglobulin locus. The translocations are caused by errors in two developmentally regulated DNA recombination processes: V(D)J and IgH switch recombination. Both processes share the property of joining discontinuous sequences from one chromosome and releasing intervening sequences as circ...

The authors investigated how 3- and 4-year-old children and adults use relative distance to judge nearbyness. Participants judged whether several blocks were by a landmark. The absolute and relative distance of the blocks from the landmark varied. In Experiment 1, judgments of nearbyness decreased as the distance from the landmark increased, particularly for 4-year-olds and adults. In Experimen...

This paper reviews issues in and procedures for the safety evaluation of in-vehicle Advanced Driver Assistance Systems. Contrasts are drawn between the two main areas of driver assistance systems — on the one hand information systems which interact with the driver and on the other hand intervening systems which interact directly with the vehicle. Navigation systems are typical of the former cat...

A gastrin gene was isolated from a genomic library of human DNA. The human gastrin gene is about 4100 base pairs long and contains two intervening sequences. Thus, a 3500-base-pair intervening sequence is located 5 base pairs proximal to the ATG initiator codon, while a 129-base-pair intervening sequence separates the region coding for the principal hormonal form of gastrin, the heptadecapeptid...

Information related to the self tends to be better remembered than other information. Mentalization (i.e., attributing mind to an external entity) is one potential intervening factor in contrasting myself, others “like me”, and inanimate objects. Twenty-seven undergraduates (mean age 23.6 years, 16 women) responded to a Remember/Know (R/K) recognition task. In the study phase, 78 words were pre...

Attention and interpretation biases are closely involved in depression. However, it is unclear whether they reflect processing tendencies (i.e., driven by schemas) and/or ability-related processes (i.e., dependent on attentional control). This study tested depressive symptom severity, attention bias, and interpretation bias associations under both processing conditions. Fifty-two participants c...

The transcription of structural and intervening sequences of the chicken ovalbumin gene was studied in nuclei isolated from the oviduct, liver, and spleen of chickens in different states of estrogen simulation. The concentration of transcripts of structural and intervening DNA sequences was determined by hybridizing the newly synthesized [(3)H]RNA to filters containing cloned ovalbumin cDNA (pO...

Diagnoses of living conditions and health status, the constitutive elements for the reproduction of social life in various places, are listed and treated as contents disconnected from the territory. The recognition of social dynamics, habits, and customs is highly important for the determination of human health vulnerabilities, which originate in the interactions of social groups in given geogr...