Continuous lymphoblastoid cell cultures were established from marmoset (Saguinus sp.), squirrel (SaimirÃ-sciureus), owl (Aotus trivirgatus), and cebus (Cebus apella) monkeys after their peripheral lymphocytes were cultured with lethally, X-irradiated cells carrying Epstein-Barr virus (EBV). Simian lymphocytes were also transformed after exposure to infectious, cell-free EBV derived from some si...

A sequential study is reported of the cytological changes induced in cultures of monkey kidney epithelial cells by poliovirus. The pattern of cytological changes was followed through a single cycle of virus multiplication. Morphological alterations were correlated with the appearance of new infective virus within the cells and in the culture fluid. Alteration of the chromatin pattern of the nuc...

Continuous lymphoblastoid cell cultures were established from marmoset (Saguinus sp.), squirrel (SaimirÃ-sciureus), owl (Aotus trivirgatus), and cebus (Cebus apella) monkeys after their peripheral lymphocytes were cultured with lethally, X-irradiated cells carrying Epstein-Barr virus (EBV). Simian lymphocytes were also transformed after exposure to infectious, cell-free EBV derived from some si...

A reference strain (Movár 33/63) of bovine herpesvirus type 4 (BHV-4) was inoculated into 14 different human cell lines and five primary cell cultures representing various human tissues. BHV-4 replicated in two embryonic lung cell lines, MRC-5 and Wistar-38, and in a giant-cell glioblastoma cell culture. Cytopathic effect and intranuclear inclusion bodies were observed in these cells. PCR detec...

Neoplastic reticulosis of the central nervous system was associated with intracytoplasmic inclusion bodies in Purkinje cells and neurons of several nuclei. These eosinophilic inclusion bodies were from round to crescentic and had a different location, structure, and cytochemistry than Negri bodies and inclusions of other canine neurologic diseases. The inclusions represent an aberration of roug...

  Urinary N-acetyl-β-D-glucosalninidase (NAG) has been proved to be a useful marker of early renal injury as a result of factors such as lead toxicity. In this study the effect of lead acetate on the kidney and its correlation with the nitric oxide (NO) system was investigated by determining the NAG release in perfused kidney of rat. Lead acetate caused a time- and dose-dependent increase in en...

BACKGROUND Neuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in neuronal and somatic cells. Because of the variety of clinical manifestations, antemortem diagnosis of NIID is difficult. METHODS Seven skin biopsy samples from patients with familial NIID were evaluated histochemically, and the ...

objective: nanosilver has numerous applications in medicine due to its potent antibacterial activity. however, data regarding the bio-safety of its effective concentrations is scarce. this study aims to assess the toxicity of silver nanoparticles on human gingival epithelial cells under in-vitro conditions.   methods: this in vitro study evaluated the toxic effects of filtered and unfiltered na...