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A hallmark of liver fibrosis is the activation of hepatic stellate cells (HSC), which results in their production of fibrotic molecules, a process that is largely regulated by connective tissue growth factor (CCN2). CCN2 is increasingly expressed during HSC activation because of diminished expression of microRNA-214 (miR-214), a product of dynamin 3 opposite strand (DNM3os) that directly suppre...

PURPOSE HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events. We conducted a dose escalation study of HMN-214 in patients with advanced cancer to assess the safety profile and pharmacokinetics of HMN-214 and to establish the maximum tolerated dose...

This contribution addresses the questions:  Why International Standards?  What is ISO?  How does ISO develop standards? The focus are the Key principles in standard development: 1. ISO standards respond to a need in the market 2. ISO standards are based on global expert opinion 3. ISO standards are developed through a multi-stakeholder process 4. ISO standards are based on a consensus Finall...

Background: Myocardial infarction (MI) is one of the most important causes of death worldwide. The effect of flunixin meglumine (FM) on MI is unknown. We investigated the protective effect of FM on the serum biochemical profile, malondialdehyde (MDA), and heart histology changes induced by isoproterenol (ISO) in adult male rats. Methods: Rats were randomly divided into four groups of six eac...

In annotating measure expressions such as three days and about 123 km, two recently published ISO standards, ISO-TimeML (ISO, 2012b) and ISOspace (ISO, 2014a), show some inconsistencies, as pointed out in ISO SemAF Principles (ISO, 2014c), a third ISO standards on semantic annotation to be published soon. Other than terminological or semantic inconsistencies introduced in ISO SemAF Principles, ...