welcome unanimity in UK media treatment of a recent paper on measles, mumps, rubella (MMR) vaccine in the Archives of Disease in Childhood. This was a review by David Elliman of St George’s Hospital and Helen Bedford of the Institute of Child Health, London, of all the evidence concerning alleged links with autism and inflammatory bowel disease. They concluded that there were no such links –— b...

Recent studies point to a diverse assemblage of prokaryotic cognates of the eukaryotic ubiquitin (Ub) system. These systems span an entire spectrum, ranging from those catalyzing cofactor and amino acid biosynthesis, with only adenylating E1-like enzymes and ubiquitin-like proteins (Ubls), to those that are closer to eukaryotic systems by virtue of possessing E2 enzymes. Until recently E3 enzym...

ysis sampling in pharmacokinetics research has proven to have many benefits such as clean samples, more frequent samples, conservation of body fluid, and fewer animals per study. In addition, it provides a direct profile of pharmacokinetics within the tissue of interest instead of traditional methods which calculate the tissue concentration indirectly from serial blood samples. Microdialysis sa...

The Lancet Palestinian Health Alliance (LPHA), established in 2009, following the Series on health and care occupied territory, is an informal network of Palestinian, regional, international colleagues researching Palestinians. Ten annual scientific conferences have been held, with 748 research presentations involving more than 1000 coauthors. LPHA has no representative or political purpose pre...

Local coupled-cluster singles–doubles theory (LCCSD) is a theorist’s attempt to capture electron–electron correlation in a fast amount of time and with chemical accuracy. Many of the difficult computational hurdles have been navigated over the last twenty years, including how to construct a linear scaling algorithm and how to produce smooth potential energy surfaces. Nevertheless, there remains...

“It’s all a result of scaremongering by the media,” said a general practitioner, speaking on a British breakfast TV station on 8 February. She was referring to public concern in Britain over the alleged risks of MMR (measles, mumps, rubella) vaccine. This has meant that uptake of the vaccine has declined steeply in some parts of the country, leading to significant increases in the numbers of ch...

While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified. Species of Bacteroides and their relatives, which often comprise .50% of the gut community, are unusual among bacteria in that their membrane is rich in sphingolipids, a class of signaling molecules that play a key role in inducin...

[Color figure can be viewed at wileyonlinelibrary.com]Robert Theodore Leshner, MD, died on February 12, 2021, age 76, home, after a heroic, 10-year struggle with multiple system atrophy. He was born in 1944 Brooklyn, New York. His father physician and an influential role model. In high school, Bob wrestled played lacrosse soccer. received his undergraduate degree from Cornell University 1965 gr...

Generalized Painlevé-Gullstrand coordinates for stationary axisymmetric spacetimes are constructed explicitly; and the results are applied to the Kerr-Newman family of rotating black hole solutions with, in general, non-vanishing cosmological constant. Our generalization is also free of coordinate singularities at the horizon(s); but unlike the Doran metric it contains one extra function which ...

It is all hands on deck to fight misinformation and vaccine hesitancy in Indonesia, more than a year into the COVID-19 pandemic. To enhance confidence, President Joko Widodo had his first jab at start of national vaccination drive January 13, 2021. He received shot Coronavac, developed by China's Sinovac Biotech that was earlier approved for emergency use Indonesia's food drug control agency. H...