Iron (Fe) is an environmental and industrial pollutant that affects various organs in human and animals. A body of evidence implicates that the free radical generation with subsequent oxidative stressis involved in the mechanism of Fe toxicity. Since the kidney is critical target of Fe toxicity we carried out this study to investigate the effect of Ellagic acid (EA), a polyphenolic compound on ...

background: this study was undertaken to examine the reversibility of renal injury in the male new zealand white rabbits sub­se­quent to a 90-days exposure to uranyl nitrate (un) in drinking water. animals were exposed for 90 days to uranyl ni­trate in their drinking water (24 or 500mg/l). control group were given municipal tap water. methods: the indicators of kidney function measured in this ...

Cadmium (Cd) poses a great threat to the breeding of aquatic economic animals. The present study aimed explain antagonistic effects selenium-enriched Lactobacillus plantarum (SL) on Cd toxicity through expression oxidative and inflammatory factors. A total 225 Bulatmai barbel Luciobarbus capito (L. capito) were divided into 3 groups, namely, control group, group (Cd, 0.05 mg·L−1), SL + mg·L−1; ...

The effect of biopesticide - Derisom on certain metabolites and enzymes of carbohydrate metabolism were evaluated in gill, liver, kidney and muscle of Cyprinus carpio during sub-lethal toxicity exposure of 21 days. A dose of 0.28 ppm was taken as the sub-lethal dose. The organs were taken from exposed and control fish at the end of 24 hrs, 7, 14 and 21 days and used for the estimation of total ...

Background: Hexachlorobutadiene (HCBD), a potent nephrotoxin can cause degeneration and necrosis in renal tubular epithelial cells in rodents. Its toxicity is due to conjugation with glutathione to form the related cysteine conjugate. This metabolite is then taken up by the kidney and cleared through renal tubular epithelial cells as a reactive thiol derivative by the enzyme β-lyase. Objective:...

Banana peel and pineapple contain potassium which may be developed into health supplements. The development of banana peels as ingredients for supplements must meet safety aspects that can proven by subchronic toxicity tests. This test aimed to determine the effect repeated administration a combination extract 28 days on liver, kidney, lung, heart, spleen index Wistar rats. research used male f...

Objective(s): The wide scale use of Zinc oxide nanoparticles (ZnO NPs) in the consumer market world makes human beings more prone to the exposure to ZnO nanoparticles and its adverse effects. Therefore, the aim of the present study is to assess renal toxicity potential of ZnO and Polyethylene glycol Coated ZnO Nanoparticles in rat.Materials and Methods: Co-precipitation chemical method was used...

Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water ethanol-water extracts administrations on oxidative stress paracetamol-induced nephrotoxicity. For this purpose, 30 rats were divided into 5 groups: control, neg...