Studies of ultimate attainment in adult second-language (L2) acquisition report a disjunction between success in acquiring the syntax of the target language (TL), on the one hand, and persistent difficulties at the interfaces of syntax with other grammatical modules, e.g. discourse-pragmatics, on the other. However, there continues to be debate as to whether these difficulties arise from devian...

Abstract Task-based language teaching has received increased attention in second language research. However, the combination of structured input-based approach and task-based language teaching has not been examined in relation to L2 grammar learning. To address this gap, the present study investigated how the structured input-based tasks with and without explicit information impacted learners’ ...

BACKGROUND Blocking the binding between the PD-1 and PD-L1 has been reported to produce antitumor responses. The MET/HGF axis appears to be another signaling pathway frequently altered in small cell lung cancer (SCLC). Our study was aimed to investigate the expression and prognostic roles of PD-L1 and c-MET in SCLC. METHODS The expression levels of PD-L1 and c-MET were evaluated by immunohist...

Our goal is to predict the first language (L1) of English essays’s authors with the help of the TOEFL11 corpus where L1, prompts (topics) and proficiency levels are provided. Thus we approach this task as a classification task employing machine learning methods. Out of key concepts of machine learning, we focus on feature engineering. We design features across all the L1 languages not making us...

Three laboratories participated with their laboratory-specific microbiologic growth assays (MA) in the NHANES 2007-2008 to assess whether the distributions of serum (n = 2645) and RBC folate (n = 2613) for the same one-third sample of participants were comparable among laboratories. Laboratory (L) 2 produced the highest and L1 the lowest serum and RBC folate geometric means (nmol/L) in the NHAN...

The insulin signaling pathway has been reported to mediate R-alpha-lipoic acid- (R-LA-)-stimulated glucose uptake into 3T3-L1 adipocytes and L6 myotubes. We investigated the role of the thiol antioxidant dihydrolipoic acid (DHLA) and intracellular glutathione (GSH) in R-LA-stimulated glucose transport and explored the hypothesis that R-LA could increase glucose uptake into 3T3-L1 adipocytes in ...

BACKGROUND Deep hypothermic circulatory arrest (DHCA) has been used in cardiac surgery involving infant complex congenital heart disease and aortic dissection. DHCA carries a risk of neuronal apoptotic death in brain. Serum ubiquitin C-terminal hydrolase L1 (UCH-L1) level is elevated in a number of neurological diseases involving neuron injury and death. We studied the hypothesis that UCH-L1 ma...

Quite often a machine learning problem lends itself to be split in several well-defined subproblems, or tasks. The goal of Multi-Task Learning (MTL) is leverage the joint from two different perspectives: on one hand, single, overall model, and other hand task-specific models. In this way, found solution by MTL may better than those either common Starting with work Evgeniou et al., support vecto...

Abstract Background Anti-PD-1/PD-L1 immunotherapy is a promising treatment for ESCC. High PD-L1 expression theoretical predictive biomarker, but the poor response also observed in some patients with high expression. Biopsies assessment of always focuses on single region which may be influenced by spatial heterogeneity tumor microenvironment. This study investigates whether biopsy different regi...