The state-of-the-art review by Tung and colleagues provides a thoughtful perspective on balancing the benefits and risks of implantable cardioverter-defibrillator (ICD) therapy addressing the concerns of many caring physicians. In this response: 1) the clinical benefits of ICD therapy are reviewed using the evidence base resulting from controlled clinical trials; 2) untoward effects of ICDs on ...

abstract background: level of stress and its management affects the dimensions of psychosomatic patients’ quality of life (qol), which is an important psychological issue. the present study aimed to investigate the effect of cognitive behavioral stress management program on psychosomatic patients’ qol. in cognitive behavioral method, patients discover thought and behavioral mistakes and recover...

6 The objective of this review article was to evaluate the current literature on the increasing off-label use of rFVIIa in the management of critical obstetric hemorrhage. Given the lack of high-level evidence, there is a need to review the clinical indications, observed response and adverse events. This review is designed to aid practitioners in deciding when and how to administer rFVIIa; It m...

Despite the first application of gene therapy in 1990, gene therapy has until recently failed to meet the huge expectations set forth by researchers, clinicians, and patients, thus dampening enthusiasm for an imminent cure for many life-threatening genetic diseases. Nonetheless, in recent years we have witnessed a strong comeback for gene therapy, with clinical successes in young and adult subj...

Purpose Tai Chi, a Chinese mind-body exercise, has a complex multicomponent therapy that integrates physical, psychosocial, emotional and behavioral elements to promote health in a variety chronic condition. Health Related Quality of Life (HRQL) is a multidimensional, subjective patient centered outcome that encompasses those conditions that affects a person’s overall well-being. A comprehensiv...

Thyroid cancer represents a spectrum of biological and molecular activity. As such it can behave in a variety of ways. This makes metastatic thyroid cancer challenging to manage. In advanced rapidly progressive thyroid cancer new agents and multimodality care represent promising therapeutic options for patients. However, these agents are not without risk and clinicians must be judicious with th...