The location-routing problem is the most significant and yet new research field in location problems that considers simultaneously vehicle routing problem features with original one for achieving high-quality integrated distribution systems in beside of the global optimum. Simultaneous pickup and delivery based on time windows are the two main characteristics of logistic management that have be...

Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...

This paper concerns indoor location determination by using existing WLAN infrastructures and WLAN enabled mobile devices. The location fingerprinting technique performs localization by first constructing a radio map of signal strengths from nearby access points. The radio map is subsequently searched using a classification algorithm to determine a location estimate. This paper addresses two dis...

Wireless sensor network (WSN) scalability and energy-efficiency issues remain an interesting research problem. This paper presents a multiple-sink deployment scheme for large-scale WSNs. An 8-rings Corona style sensor network is regarded as a Corona Sensor Cell (CSC) based on coarse-grain location awareness for energy-efficiency consideration. The overall task includes nodes training and data d...

In this paper, we propose an efficient hybrid location algorithm with BP neural networks. We choose two-layer backpropagation network for data fusions and position estimation to improve hybrid location accuracy and efficiency with TOA/TDOA/AOA parameters in mobile communication networks. So the position estimation can be optimized by network parallel processing robustly, and the inaccuracy or f...

Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus,...