نتایج جستجو برای: metabolome profile
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Metabolic profiling, also known as metabonomics (Nicholson et al., 1999) or metabolomics (Raamsdonk et al., 2001), is a rapidly developing field in biomedical science that combines the application of spectroscopic techniques with multivariate statistical analysis in studies of the molecular composition of biofluids, cells and tissues. The experimental focus is on profiling metabolites the thous...
Tumor cells respond to growth signals by the activation of protein kinases, altered gene expression and significant modifications in substrate flow and re-distribution among biosynthetic pathways. This results in a proliferating phenotype with altered cellular function. These transformed cells exhibit unique anabolic characteristics, which includes increased and preferential utilization of gluc...
INTRODUCTION Non-malaria febrile illnesses such as bacterial bloodstream infections (BSI) are a leading cause of disease and mortality in the tropics. However, there are no reliable, simple diagnostic tests for identifying BSI or other severe non-malaria febrile illnesses. We hypothesized that different infectious agents responsible for severe febrile illness would impact on the host metabolome...
The purpose of this study was to reveal the changes in total phenolic content and antioxidant capacity broccoli, an untargeted metabolomics approach developed investigate effect lactic acid bacteria fermentation on metabolome broccoli florets. results showed that significantly increased after fermentation. metabolite profile main chemical components fermented unfermented are lipids lipid-like m...
Rice bran (RB) consumption has been shown to reduce colorectal cancer (CRC) growth in mice and modify the human stool microbiome. Changes in host and microbial metabolism induced by RB consumption was hypothesised to modulate the stool metabolite profile in favour of promoting gut health and inhibiting CRC growth. The objective was to integrate gut microbial metabolite profiles and identify met...
Profiling of body fluids is crucial for monitoring and discovering metabolic markers of health and disease and for providing insights into human physiology. Since human urine and plasma each contain an extreme diversity of metabolites, a single liquid chromatographic system when coupled to mass spectrometry (MS) is not sufficient to achieve reasonable metabolome coverage. Hydrophilic interactio...
BACKGROUND Maize (Zea mays L.) is one of the most widely cultivated crop plants. Unavoidable economic and environmental problems associated with the excessive use of phosphatic fertilizers demands its better management. The solution lies in improving the phosphorus (P) use efficiency to sustain productivity even at low P levels. Untargeted metabolomic profiling of contrasting genotypes provides...
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