La contribución analiza los mecanismos con que Amélie Nothomb, en su novela Les prénoms épicènes (2018), establece un proceso de recombinación y reescritura a partir diferentes formas “mito”. El relato convierte la relación explícita comedia Epicoene (1609) Ben Johnson el recurso al mito órfico instrumentos escenificación irónica clichés asociados identidad femenina.

We prove that the linear delta expansion for energy eigenvalues of the quantum mechanical anharmonic oscillator converges to the exact answer if the order dependent trial frequency Ω is chosen to scale with the order as Ω = CN ; 1/3 < γ < 1/2, C > 0 as N → ∞. It converges also for γ = 1/3, if C ≥ αcg, αc ≃ 0.570875, where g is the coupling constant in front of the operator q/4. The extreme case...

Lactic acidemia is one manifestation of the mitochondrial diseases caused by pathogenic mutant mitochondrial DNA (mtDNA). However, little is known about its chronic effects in the progression of mitochondrial disease phenotypes. To obtain experimental evidence on this point, we used trans-mitochondrial model mice (mito-mice) heteroplasmic for wild-type and deleted mtDNA (DeltamtDNA). Mito-mice ...

Intracellular trafficking of viruses and proteins commonly occurs via the early endosome in a process involving Rab5. The RNA Import Complex (RIC)-RNA complex is taken up by mammalian cells and targeted to mitochondria. Through RNA interference, it was shown that mito-targeting of the ribonucleoprotein (RNP) was dependent on caveolin 1 (Cav1), dynamin 2, Filamin A and NSF. Although a minor frac...

Prototypical electrophiles such as the lipid 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) are well recognized for their therapeutic potential. Electrophiles modify signalling proteins in both the cytosol and mitochondrion, which results in diverse cellular responses, including cytoprotective effects and, at high doses, cell death. These findings led us to the hypothesis that targeting electr...

Store-operated Ca(2+) entry (SOCE) is established by formation of subplasmalemmal clusters of the endoplasmic reticulum (ER) protein, stromal interacting molecule 1 (STIM1) upon ER Ca(2+) depletion. Thereby, STIM1 couples to plasma membrane channels such as Orai1. Thus, a close proximity of ER domains to the plasma membrane is a prerequisite for SOCE activation, challenging the concept of local...

Adipocytes are the primary cells in the body that store excess energy as triglycerides. To perform this specialized function, adipocytes rely on their mitochondria; however, the role of adipocyte mitochondria in the regulation of adipose tissue homeostasis and its impact on metabolic regulation is not understood. We developed a transgenic mouse model, Mito-Ob, overexpressing prohibitin (PHB) in...

Endothelial migration is a crucial aspect of a variety of physiologic and pathologic conditions including atherosclerosis and vascular repair. Reactive oxygen species (ROS) function as second messengers during endothelial migration. Multiple intracellular sources of ROS are regulated by cellular context, external stimulus, and the microenvironment. However, the predominant source of ROS during ...

and it is an important factor that leading to cardiac ischemiareperfusion injury. In the past, most attention was focused on cardiac cells. While in recent years, myocardiac microvascular endothelial cells (MMECs) attracted scholar’s attention. The one hand, endothelial cells participate in many important body balance regulation, and can synthesize and secrete a variety of biologically active s...

Recent studies have reported spread of pathogenic proteins in the mammalian nervous system, but whether nonpathogenic ones spread is unknown. We initially investigated whether spread of a mutant amyotrophic lateral sclerosis-associated cytosolic superoxide dismutase 1 (SOD1) protein between motor neurons could be detected in intact chimeric mice. Eight-cell embryos from G85R SOD1YFP and G85R SO...