New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer,...

Tóm tắt:
 Thực trạng ô nhiễm môi trường do phế thải tro bay vẫn còn rất nghiêm trọng. Nghiên cứu này sử dụng trực tiếp với hàm lượng mất khi nung (MKN) cao ở ướt để thay thế một phần cát tự nhiên trong vữa xi măng, nhằm giải quyết bài toán thiếu hụt xây dựng. Trong phạm vi nghiên cứu, mẫu được kiểm soát tỉ lệ nước:xi măng bằng 0,6, lần lượt là 0%, 10%, và 20% theo thể tích. Độ chảy xòe cườ...

The radiative loss interpretation for the broken power-law spectra of blazars is often questioned since difference between indices does not support this inference. Using blazar Mkn 421 as a case study, we performed detailed analysis its characteristic photon energy where spectral index changes significantly. We used observations source by Swift-XRT from 2008 to 2019 identify and corresponding i...

Background: In vitro biofilm formation of H. pylori is demonstrated; however, its potential role in the persistent infection human stomach has not yet been addressed. Objectives: The aim this study was to assess clinical isolates on an epithelial cell line, a line that produces mucin. Methods: consisting efficient (19B) and weak (4B) ability, were selected from screening isolates. Their adhesio...

Optically thin two-temperature accretion flows may be thermally and viscously stable, but acoustically unstable. Here we propose that the O-mode instability of a cooling-dominated optically thin two-temperature inner disk may explain the 23day quasi-periodic oscillation (QPO) period observed in the TeV and X-ray light curves of Mkn 501 during its 1997 high state. In our model the relativistic j...

Investigation of the mechanisms of resistance to targeted therapies is essential as resistance acquired during treatment may lead to relapse or refractoriness to the therapy. Our previous study identified the small molecule KRC-108 as a result of efforts to find an anticancer agent with c-Met-inhibitory activity. In the present study, the changes accompanying resistance to KRC-108 were investig...