BACKGROUND The only human cathelicidin, LL-37, and the innate defense regulator peptide IDR-1, which have been proven to have antimicrobial activity, represent essential elements of immunity. Our previous study showed that the peptide LL-37 was protective in vitro to attenuate LTA-induced inflammatory effects. Methicillin-resistant staphylococcus aureus (MRSA) causes a multitude of serious and ...

Tedizolid (TR-700, formerly torezolid) is the active moiety of the prodrug tedizolid phosphate (TR-701), a next-generation oxazolidinone, with high potency against Gram-positive species, including methicillin-resistant Staphylococcus aureus (MRSA). A recently completed randomized, double-blind phase 2 trial evaluated 200, 300, or 400 mg of oral tedizolid phosphate once daily for 5 to 7 days in ...

Antimicrobial resistance (AMR) is one of the biggest public health challenges this century. The misuse and/or overuse antibiotics has triggered rapid development AMR mechanisms. Fluoroquinolones (FQs) are a broad-spectrum family antibiotics, widely used in clinical practice. However, several mechanisms against have been described. Our strategy to bypass problem their complexation with copper an...

Ceftaroline is a novel broad-spectrum cephalosporin β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as multidrug-resistant Streptococcus pneumoniae among other routine Gram positive and Gram negative organisms. It has been approved by the US Food and Drug Administration for treatment of community-acquired bacterial pneumonia and acute bacteri...

In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P < 0.05). ...

In this study the extracellular proteins from isolate LC3 belonging to Aspergillus were purified for new antimicrobial polypeptide (AMP) discovery and then tested activity against Staphylococcus aureus (ATCC 25923) Methicillin-resistant S. (MRSA). Antimicrobial was determined by trypsin/proteinase K assay, which polypeptide-based, it observed that protein a of about 11 kDa gel overlay assay. Th...

The green synthesis of Ag/AgCl nanocomposite using the durian shell extract was carried out under sunlight illumination at room temperature, showing face-centered cubic crystalline structures both Ag and AgCl with nanosizes in range 15–25 nm. high negative potential value solution (–21.1 mV) established dispersion Ag/AgCl, long-term stability, good colloidal nature. antibacterial activity again...

methicillin-resistant Staphylococcus aureus (MRSA) in hospitals have become a serious clinical problem. A glycopeptide antibiotic, vancomycin, has been used for the treatment of infections due to MRSA. Enterococci, which have some a part of the normal faecal flora of humans and animals have generally emerged as important nosocomial pathogens. Acquired resistance to vancomycin and teicoplanin in...

Background: Once identified as Staphylococcus aureus, it is imperative to understand their methicillin resistance status for institution of appropriate therapy. Conventional disc diffusion tests may not accurately identify MRSA strains and may not be in concordance with PCR results. Objectives: Relative abilities of phenotypic and molecular methods to detect MRSA strains was evaluated to unders...