conclusions the trat gene and pai markers were highly prevalent among upec strains isolated from patients in kashan, iran; therefore these determinants could be used as targets for prophylactic interventions. also there was a high level of resistance against the antibiotics commonly used for urinary tract infection treatment. to reach better therapeutic outcomes, treatment regimens have to be m...

BACKGROUND The resistance of aminoglycosides in strains that produce beta-lactamase can be developed through the multidrug resistant encoding genes carried by common plasmids. Recently, the association between 16S rRNA methyltransferase resistance and beta-lactamase enzymes carried by the same plasmids has drawn increased attention from researchers, particularly the association in aminoglycosid...

BACKGROUND Multidrug resistance (MDR) is one of the major reasons chemotherapy-based treatments fail. Hypoxia is generally associated with tumor chemoresistance. However, the correlation between the heterodimeric hypoxia-inducible factor-1 (HIF-1) and the multidrug resistance (MDR1) gene/transporter P-glycoprotein (P-gp) remains unclear. This study aims to explore the molecular mechanisms of re...

Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...

background and objective:acinetobacter spp.a gram-negative coccobacillus is increasingly reported as important cause of nosocomial infections. multi-drug resistance (mdr) ofacinetobacterspp., raises concerns over our ability to treat serious infections with these organisms. the aim of this study was to determine the frequency and associated risk factors for infections with mdr acinetobacter spp...

background and objectives: β-lactamase production is the predominant mechanism for resistance to β-lactams in enterobacteriaceae. the producing isolates are often multidrug resistant and are major hosts for extended spectrum β-lactamases. this study was designed to determine the prevalence of extended-spectrum β-lactamase producing isolates of escherichia coli and klebsiella pneumoniae and thei...

BACKGROUND To identify novel proteins involved in multidrug resistance in chronic myeloid leukemia (CML). MATERIALS AND METHODS Comparative proteomics was used to screen multidrug resistance-related proteins from K562 and K562/A02; the differently expressed proteins were further confirmed by western blot and real-time PCR. short hairpin RNA (shRNA) assay was applied to determine the relations...

Background: Acinetobacter baumannii is a highly virulent bacterium. It causes opportunistic and nosocomial infections and is a threat to healthcare settings. It has also developed multidrug resistance (MDR) capacity. The nosocomial bacteria and antibiotic resistance are primordial and a significant public health concern. These bacteria and their threat can be prevented by reducing infected food...