Most Korean patients with non-insulin-dependent diabetes mellitus (NIDDM) have been reported not to be obese, and many of them lost weight significantly during the course of their disease. In this regard, a retrospective cohort study was conducted to determine the relationship between body mass index (BMI, kg/m2) and the risk for NIDDM among Koreans. Subjects who had received a medical examinat...

BACKGROUND The relative roles of obesity, insulin resistance, insulin secretory dysfunction, and excess hepatic glucose production in the development of non-insulin-dependent diabetes mellitus (NIDDM) are controversial. We conducted a prospective study to determine which of these factors predicted the development of the disease in a group of Pima Indians. METHODS A body-composition assessment...

OBJECTIVE The aim of this study was to estimate the effect of metformin on the serum total homocysteine level in non-insulin-dependent diabetes mellitus (NIDDM) patients. An elevated serum total homocysteine level is a risk factor for atherosclerosis. Metformin decreases serum vitamin B12, and may thereby indirectly increase the serum total homocysteine level. DESIGN A cross-sectional study i...

The ability of high viscosity hydroxypropylmethylcellulose (HPMC) to reduce postprandial glucose concentrations was assessed in patients with non-insulin-dependent diabetes (NIDDM) and healthy volunteers. The study design consisted of a two-way crossover, single-dose administration of 10 g prehydrated high viscosity HPMC, or placebo, with a standard carbohydrate-rich meal. In patients with NIDD...

Coronary heart disease risk factor levels were studied in 184 first-degree relatives (sisters and brothers) of non-insulin-dependent diabetic subjects (124 relatives with normoglycemia, 34 relatives with impaired glucose tolerance [IGT], and 26 relatives with non-insulin-dependent diabetes mellitus [NIDDM]) and in 215 relatives of nondiabetic subjects (194 relatives with normoglycemia and 21 re...

To evaluate the clinical values of serum fructosamine and HbAlc, serum fructosamine and HbAlc were assessed in 50 normal controls and 36 patients with NIDDM (non-insulin-dependent diabetes mellitus). And we studied 10 patients selected at random among the 36 patients with NIDDM. The values of serum fructosamine and HbAlc in controls were 2.1 mmol/L and 5.3%, respectively. The levels of serum fr...

Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. Oxidative stress is an independent risk factor by inducing production of oxygen free radicals in cardiovascular diseases. Because a relationship may be hypothesized between Paraoxonase [PON] and Malondialdehyde [MDA], the aim of this study was to investigate the relationship between PON and oxidati...

The comprehensive longitudinal studies of diabetes conducted in the Pima Indians of Arizona over the last 30 years indicate that both genetic and environmental factors play a critical role in the pathogenesis of the disease. Pre- and postnatal exposures as well as diet and physical activity in adulthood markedly affect risk of developing NIDDM in this population. In addition, the high prevalenc...

OBJECTIVES The purpose of this study was to evaluate the ERP P300 in non insulin dependent diabetes mellitus (NIDDM) patients without cognitive impairment and the relationship with clinical variables, the presence of retinopathy and previous hypoglycemic episodes. METHODS NIDDM patients (N=44) without evidence of cognitive impairment and controls (N=17) were studied clinically and with ancill...

Background and purpose: A likely explanation for the increase in lens fluorescence with aging and the acceleration of this process in patients with diabetes, is that lens proteins are altered by non-enzymatic glycosylation and the further steps of the Maillard reaction. Thus, the lens fluorescence intensity appears to represent a cumulative index of glycemia over the entire lifetime of the subj...