Brown adipose tissue (BAT) has been noted in cadaveric specimens by anatomists for hundreds of years and is now known to be a primary peripheral the expression non-shivering thermogenesis response perturbations diet environment homeothermic species including man animals. The Wistar Fatty Rat (WFR) an animal model obesity, insulin resistance (IR) NIDDM expresses (-fa) obesity trait NIH/Wistar ba...

BACKGROUND It is not presently known whether non-insulin-dependent diabetes mellitus (NIDDM) is associated with the presence of structural alterations in small arteries or whether the combination of hypertension and NIDDM may have an additive effect on endothelial dysfunction. Therefore, we investigated subcutaneous small arteries in 12 normotensive subjects (NT group), 18 patients with essenti...

Introduction: Diabetes is a major risk factor for number of noncommunicable diseases. Novel factors like lipid profiles have contributed as risk factors for coronary artery disease along with abdominal obesity. So a comparative study is done to know the extent of altered lipid metabolism in NIDDM. Methods: Lipid profiles along with blood sugar levels were done to know the effect of dyslipidemia...

The majority (> 80%) of patients with non insulin dependent diabetes mellitus (NIDDM) present in Europe and America are obese. In developing countries like India, most NIDDM (> 60%) are non-obese and many are actually lean with a body mass index (BMI) of < 18.5 and are referred to as 'lean NIDDM'. This paper compares the clinical profile of a cohort of 347 lean NIDDM, with a group of 6274 NIDDM...

Several lines of evidence suggest a strong genetic component to NIDDM. To clarify the role of glucokinase gene in the development of NIDDM, restriction fragment length polymorphism (RFLP) of glucokinase gene and 3' microsatellite polymorphism analyses by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) were performed in NIDDM and control subjects. Compared to NIDDM...

BACKGROUND The high prevalence and severe consequences of non-insulin dependent diabetes mellitus (NIDDM) in Taiwan calls for urgent measures to detect this disease in the asymptomatic phase. However, the efficacy of early detection of NIDDM is highly dependent on its natural history from the disease-free state, through the asymptomatic to the symptomatic phase and death from NIDDM or other cau...

Non-insulin-dependent diabetes (NIDDM) is an important contributor to premature vascular disease', blindness2, renal failure3 and lower limb amputation.4 Morbidity and mortality from NIDDM is under-reported as NIDDM is frequently undiagnosed, the diagnosis often being excluded from death certificates5 and hospital discharge summaries.6 Despite the cumulative incidence of diabetic microvascular ...

Several candidate genes for non-insulin-dependent diabetes mellitus (NIDDM) map on chromosome 20, including the phosphoenolpyruvate carboxykinase gene (PCK1) and one of the maturity onset diabetes of the young genes (MODY1). Thus, we have investigated the entire long arm of chromosome 20. Linkage analyses were conducted in a total sample of 148 NIDDM families (301 NIDDM sib pairs) and in a subs...

However, it has also been recognized that the treatment of NIDDM patients frequently is inadequate even in those patients who should achieve the target range. In a recent population based cohort the median of glycosylated haemoglobin was 10.2% in NIDDM patients treated with diet or oral hypoglycemic agents (OHA) and 11.8% in NIDDM patients who used insulin. In a 5 year follow-up study of NIDDM ...