Notch signaling is a conserved pathway of communication between neighboring cells that results in cell fate specification, and CSL is the universal transcriptional effector of Notch signaling. The Notch intracellular domain translocates to the nucleus after proteolytic release upon Notch extracellular engagement, and there it displaces corepressors from DNA-bound CSL and recruits activators of ...

We present a Communication-efficient Surrogate Likelihood (CSL) framework for solving distributed statistical inference problems. CSL provides a communication-efficient surrogate to the global likelihood that can be used for low-dimensional estimation, high-dimensional regularized estimation and Bayesian inference. For low-dimensional estimation, CSL provably improves upon naive averaging schem...

We present CCMC (Conditional CSL Model Checker), a model checker for continuous-time Markov chains (CTMCs) with respect to formulas specified in continuoustime stochastic logic (CSL). Existing CTMC model checkers such as PRISM or MRMC handle only binary CSL until path formulas. CCMC is the first tool that supports algorithms for analyzing multiple until path formulas. Moreover, CCMC supports a ...

Microbial polysaccharides are of great biotechnological and commercial interest have wide application in the food, cosmetic medicine industries. Exopolysaccharide (EPS) production by yeast Cryptococcus laurentii SD7, isolated from fresh water molluscs, was studied using agro-industrial byproducts as substrates submerged fermentation. The Central Composite Design (CCD) 23 used to study influence...

An experiment was conducted to evaluate the efficacy of intra-amnion administration of different doses of ascorbic acid (AA) on hatchability, growth performance, blood metabolites, jejunal morphology, and tibia breaking strength in 36h post hatch fasted broiler chickens. Two hundred eighty-eight Ross-308 fertile eggs at the 15thday of incubation were divided into four treatment groups, each con...

This study was conducted in order to evaluate effect of organic acids on broiler performance. Totally 180 chickens of Ross 308 hybrid were divided to three groups. Experimental group no. 1 (n=60) received acetic acid in drinking water with concentration 0.25% from day 1 to day 42. Experimental group no. 2 (n=60) received citric acid in drinking water with concentration 0.25% from day 1 to day 4...

Human learners can resolve referential ambiguity and discover the relationships between words and meanings through a cross-situational learning (CSL) strategy. Some people with aphasia (PWA) can learn word-referent pairings under referential uncertainty supported by online feedback. However, it remains unknown whether PWA can learn new words cross-situationally and if such learning ability is s...

the aim of this study is to find the optimal water pressure and percentage of supply vapour in the feed water heaters (fwhs) of steam power plants, such that they maximize the thermal efficiency of the rankine cycle within pre-specified values of minimum and maximum pressures of the thermodynamic cycle. thermal efficiency is defined as a function of unknown variables (fluid pressure and vapour ...