giant cell tumors (gct) are benign tumors with potential for aggressive behavior and capacity to metastasize. although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. its histogenesis remains unclear. it is characterized by a proliferation of mononuclear stromal ce...

Background: Umbilical Cord Blood (UCB) has steadily gained prominence in haematopoietic stem cell transplantation (HSCT). Despite UCB advantages, the main disadvantage of (HSCT) is its limited dose. Initially, used to be processed and then made undergo cryopreservation as whole cord blood banking leading problem storing sufficiently large number cryoprotected units which requires vast amounts c...

This study explored the changes in bone marrow CD235a+ nucleated red blood cell apoptosis and signal pathways patients with chronic mountain sickness. We collected data from 21 sickness 20 non-chronic patients. Bone mononuclear cells, flow cytometry is used to detect apoptotic index of cells determine mitochondrial membrane potential; reverse transcription quantitative polymerase chain reaction...

Dear Editor, We describe the diagnostic characteristics of three pediatric patients with early T-cell precursor (ETP)-ALL. All three patients had hyperleukocytosis with a white blood cell (WBC) count of more than 100.0×10/L, showed immunophenotypic findings consistent with ETP-ALL, and were positive for FLT3 mutations. The clinical and laboratory findings, including immunophenotyping results (F...

Background: The hematopoietic system is sensitive to the adverse effects of ionizing radiation. Cellular therapies utilizing mesenchymal stem cells or vascular endothelial cells have been explored as potential countermeasures for radiation hematopoietic injuries. We investigated cells cultured from amnion                ...

Umbilical cord blood (UCB) has been used for transplantation in the treatment of hematologic disorders as a source of hematopoietic stem cells (HSCs). Because of insufficient number of cord blood CD34+ cells, the expansion of these cells seems to be important for clinical application. Mesenchymal stromal cells (MSCs), playing an important role in HSCs maintenance, were used as feeder layer. Apo...

  Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal ...