The results of a previous study of the use of oral contraceptives by married women discharged from hospital with a diagnosis of thromboembolic disease in the years 1964-6 were reported by us last year. The present paper adds results relating to patients discharged during 1967 and a few data, that could not be sought previously, for patients discharged with cerebral or coronary thrombosis from t...

Oral contraceptives are classically given in a cyclic manner with 21 days of active pills followed by 7 days of placebo. In the past 4 years, new oral contraceptives have been introduced which either shorten the placebo time, lengthen the active pills (extended cycle), or provide active pills every day (continuous). These concepts are not new; extended and continuous pills were first studied in...

In this review we illustrated the case of a woman who had perimenstrual exacerbations of Darier-White disease. The disease improved markedly with the use of continuously administered oral contraceptives. This striking improvement without side-effects supports the use of oral contraceptives in women with Darier-White disease, although its role should be investigated further using controlled stud...

The volume of the left and right breasts was measured daily in four nulliparous women during normal menstrual cycles and after the use of oral contraceptives. Breast volume increased significantly in the second half of both normal and contraceptive-controlled cycles. The mean total change in volume throughout the cycle was 100 ml under natural conditions and 66 ml on oral contraceptives.

4.1 Absorption, distribution, metabolism and excretion The disposition of various formulations of oral contraceptives used in humans differs. In general, both the oestrogenic and progestogenic compounds in combined oral contraceptives are absorbed by the gut and metabolized largely in the liver. A fraction of the absorbed dose of ethinyloestradiol and several progestogens is excreted in the bil...

OBJECTIVE To determine whether use of oral contraceptives is associated with all cause and cause specific mortality. DESIGN Prospective cohort study. SETTING Nurses' Health Study, data collected between 1976 and 2012. POPULATION 121,701 participants were prospectively followed for 36 years; lifetime oral contraceptive use was recorded biennially from 1976 to 1982. MAIN OUTCOME MEASURES ...

OBJECTIVE To provide a comprehensive overview of the risk of venous thrombosis in women using different combined oral contraceptives. DESIGN Systematic review and network meta-analysis. DATA SOURCES PubMed, Embase, Web of Science, Cochrane, Cumulative Index to Nursing and Allied Health Literature, Academic Search Premier, and ScienceDirect up to 22 April 2013. REVIEW METHODS Observational...

The fluctuations of serum lipid and lipoprotein concentrations within one cycle were studied both in women using and not using oral contraceptives. High-density lipoprotein cholesterol decreased significantly from 1.47 mmol/l (57 mg/100 ml) to 1.30 mmol/l (50 mg/100 ml) during one contraceptive cycle in eight women and rose again to the initial value during the pill-free days. The mean concentr...