It is now well established that liposomes with surface associated proteins are immunogenic. Repeated administration of protein coated liposomes elicits the generation of antibodies and the elimination of proteoliposome increases markedly in animals 'immunized' with such liposomes. This immune response compromises the therapeutic potential of liposomal formulations that rely on the use of protei...

1. gamma-Globulin concentrates of antisera prepared against ovalbumin and human serum albumin were thiolated and cross-linked to form insoluble polymers. 2. These immunosorbents were of low solubility and of high capacity for homologous antigen. 3. The high specificity of these immunosorbents was demonstrated by fractionation of various binary mixtures of fluorescent ovalbumin, (131)I-labelled ...

Methods Inhibition of CRAC channel activity in Jurkat cells, cytokine release from human whole blood or PBMC, and mast cell degranulation were estimated. In vivo efficacy of the compound was determined in experimental models of asthma in guinea pigs including PAF or ovalbumin induced eosinophil infiltration into lungs ovalbumin induced histamine release from mast cells, and airway hyper-respons...

Maternal immune tolerance towards the fetus and placenta is thought to be established in part by pathways that attenuate T cell priming to antigens released from the placenta into maternal blood. These pathways remain largely undefined and their existence, at face value, seems incompatible with a mother's need to maintain a functional immune system during pregnancy. A particular conundrum is ev...

In the present study, ethanolic extract of Mesua ferrea L. stamens was investigated for its potential to reverse some features bronchial asthma in ovalbumin-induced murine model asthma. commonly called nagakeshar (Family, Calophyllaceae) is a well-known antiallergic drug Asian folk system medicines. work, pharmacological studies are done provide scientific evidence therapeutic plants allergic A...

Allergenic fining agents and processing aids from hen’s egg and cow’s milk used in wine production are hidden allergens and could demonstrate a health threat for allergic persons. Hence, the European parliament adopted Directive 2003/89/EC amending 2000/13/EC to declare ingredients, contaminations and processing aids which are known to trigger allergic reactions. The Amendment Directive 415/200...

The nucleus is the center of direction and coordination of the cell's metabolic and reproductive activities. In recent years it was found that it is formed by many functionally specialized domains. These subnuclear structures are not surrounded by membranes as the cytoplasmic organelles and their function is mostly not well understood. To obtain insights into the structural organisation of the ...

Rourea coccinea (syn. Byrsocarpus coccineus) Schum. and Thonn. (Connaraceae) is a medicinal plant that being used for the treatment of various disorders in Tropical Africa. Previously, we reported anti-inflammatory antioxidant effects ethanolic extract R. root bark (EERc). The present study aimed to test protective potential EERc treatments against ovalbumin-induced airway lung inflammatory inv...