Excess collagen deposition occurs in pulmonary fibrosis. A new study suggests that collagen overproduction may originate from cells derived from bone marrow precursors rather than parenchymal lung fibroblasts.

Proteomic analysis is a highly effective method for bacteria identification and the elucidation of protein's content in prokaryotic cells at different growth conditions. To our knowledge this approach hardly ever used characterization producers biologically active substances. The understanding changes protein profile mutant strains capable substances overproduction helps to recognize biochemica...

PURPOSE Oxidative stress is linked to early apoptosis in diabetic retinopathy, and reactive oxygen species (ROS) play a critical role in that stress. Endogenous ROS generated from attacks of mitochondria on nearby mitochondrial DNA (mtDNA) could lead to constant ROS overproduction. The authors explored the role of mtDNA oxidative damage in high glucose-induced dysfunction in human retinal vascu...

To determine and quantify the cause of nocturia in men, we describe and evaluate the relative contribution of two complementary indices of nocturia: the nocturia index (Ni), a measure of nocturnal urine overproduction, and the nocturnal bladder capacity index (NBCi), reflective of nocturnal bladder capacity. The records of 100 consecutive men with lower urinary tract symptoms (LUTS), having und...

A novel animal model of insulin resistance, the fructose-fed Syrian golden hamster, was employed to investigate the mechanisms mediating the overproduction of very low density lipoprotein (VLDL) in the insulin resistant state. Fructose feeding for a 2-week period induced significant hypertriglyceridemia and hyperinsulinemia, and the development of whole body insulin resistance was documented us...

A multicopy plasmid carrying the PDC1 gene (encoding pyruvate decarboxylase; Pdc) was introduced in Saccharomyces cerevisiae CEN. PK113-5D. The physiology of the resulting prototrophic strain was compared with that of the isogenic prototrophic strain CEN.PK113-7D and an empty-vector reference strain. In glucose-grown shake-flask cultures, the introduction of the PDC1 plasmid caused a threefold ...

Song KS, Choi YH, Kim JM, Lee H, Lee TJ, Yoon JH. Suppression of prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway. Am J Physiol Lung Cell Mol Physiol 296: L684–L692, 2009. First published February 6, 2009; doi:10.1152/ajplung.90396.2008.—The mechanism by which E-prostanoid (EP) receptor is critically involved in PGE2-induced mucin 5AC (MUC5AC) gene expression in the airway h...