Oxytocin is a nine-amino acid peptide synthesized in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. Oxytocin promotes contraction of the uterus during birth and milk ejection during breast feeding. Although oxytocin receptors are found predominantly in the breasts and uterus of females, many tissues and organs express oxytocin receptors, including the pituit...

Oxytocin has been suggested as a novel therapeutic against obesity, because it induces weight loss and improves glucose tolerance in diet-induced obese rodents. A recent clinical pilot study confirmed the oxytocin-induced weight-reducing effect in obese nondiabetic subjects. Nevertheless, the mechanisms involved and the impact on the main comorbidity associated with obesity, type 2 diabetes, ar...

Background: Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which develops in approximately 10% of trauma-exposed individuals. Currently, there are few early preventive interventions available for PTSD. Intranasal oxytocin administration early posttrauma may prevent PTSD symptom development, as oxytocin administration was previously found to beneficially impact neuro...

The effects of administration of progesterone and oestradiol on ovine endometrial oxytocin receptor concentrations and plasma concentrations of 13,14-dihydro-15-keto prostaglandin F-2 alpha (PGFM) after oxytocin treatment were determined in ovariectomized ewes. Ewes received progestagen pre-treatment, progesterone and/or oestradiol in 11 different treatment schedules. Progestagen pre-treatment ...

BACKGROUND Oxytocin receptor desensitization has been shown to occur in humans at biomolecular level and in isolated rat myometrium; however, its effect on human myometrial contractility has not been demonstrated. The objective of this in vitro study was to investigate the contractile response of human pregnant myometrium to oxytocin after pretreatment with different concentrations of oxytocin ...

BACKGROUND Oxytocin is known to be related to social behaviors, including trust. However, few studies have investigated the association between oxytocin levels and social capital. Thus, we tested the hypothesis that endogenous oxytocin levels are positively associated with social capital. We also considered whether the association differed across gender because previous studies have shown diffe...

AIM Oxytocin produces concentration-dependent relaxation of isolated isthmus and ampulla of human oviduct precontracted by histamine. The aim of our study was to investigate whether this oxytocin effect was specific and by which receptors it was mediated. METHODS We investigated effects of oxytocin and its antagonists on isolated isthmus and ampulla of the uterine tubes from 20 women who unde...

Background: The foremost cause of maternal morbidity and mortality in third-world countries is Post-Partum Hemorrhage (PPH). To prevent PPH, often Misoprostol used. This study aimed to find out the efficacy safety profile when administered rectally comparison oxytocin, avoid incidence PPH. Methods: quasi-experimental on n=72 patients were performed at Ziauddin University Hospital Karachi for 6 ...

[3H]Oxytocin, incubated with rat uterine segments, was bound specifically, and about equally, to the three particulate fractions obtained by homogenization and centrifugation at 1,000, 20,000, and 105,000 X g. There apparently was no binding in the cytosol fraction. [“H]Oxytocin, added directly to rat uterine particles sedimentmg between 1,000 and 20,000 x g, was bound with an apparent & of 1.8...