The process of passive drug absorption from the gastrointestinal tract is still poorly understood and modelled. Additionally, rapidly evolving field pharmaceutics demands efficient, affordable reliable in vitro tools for predicting vivo performance. In this work, we combined established methods quantifying diffusivity (localized UV-spectroscopy) permeability (Permeapad® plate) order to gain a b...

silicon is known to ameliorate the deleterious effects of drought on plant growth. we evaluated growth of wheat (triticum aestivum l. cv. chamran) under water-deficit stress induced by polyethylene glycol as affected by si application. in this article, the effects of si (as potassium silicate) on some parameters related to growth, chlorophyll concentration relative water content (rwc), electrol...

Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...

The poor solubility and wettability of meloxicam leads to poor dissolution and hence showing variations in bioavailability. The present study is aimed to increase solubility and dissolution of the drug using solid dispersion techniques. The solid binary systems were prepared at various drug concentrations (5-40%) with polyethylene glycol 6000 by different techniques (physical mixing, solvent ev...

The article presents a comparative description of the effect metabolically active substances and their compositions on individual physiological biochemical parameters soft wheat in drought conditions. study involved use 7 options for seed treatment: control (untreated seeds + distilled water); vitamin E solution (10-8M) - E; ubiquinone-10 Q; methionine (0.001%) M; paraoxybenzoic acid (PОBA) P; ...

Meloxicam is included in the class II Biopharmaceutical Classification System (BCS). This drug has low solubility and high permeability. The one of factors that affect dissolution rate drug. One effort to increase meloxicam by forming a solid dispersion system made using melting method. addition PEG 6000 poloxamer 188 carriers determine aims meloxicam. purpose this study characterize with matri...