We aimed to develop a high-throughput screening (HTS) system for preliminary predictions of human skin permeability by using an artificial membrane that can mimic the permeation behaviour of lipophilic and hydrophilic compounds across the human skin. In this study, we synthesized a copolymer containing poly(dimethylsiloxane) (PDMS) and poly(ethylene glycol) (PEG) 6000 and impregnated it onto a ...

Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PEG 6000 have been studied in comparison with corresponding physical mixtures and pure benzodiazepines. Selected derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The aim of this work was to report the properties of diazepamand nitrazepam-PEG 6000 solid dispersions. Differential scann...

Pharmaceutical aviailability of diclofenac sodium from solid dispersions of PEG 6000 have been studied in comparison to those of the corresponding physical mixtures and pure diclofenac sodium. The diclofenac sodium is poorly water soluble drug. The properties of diclofenac sodium-PEG 6000 solid dispersions have been determined by the methods of differential scanning calorimetry (DSC), X-ray dif...

−The purpose of this investigation was to enhance the dissolution rate of loratadine using polyethylene glycol 6000 (PEG) solid dispersions (SDs). The solubility behavior of loratadine in the presence of polyethylene glycol 4000 and polyethylene glycol 6000 in water showed linear increase with increasing concentrations of PEG, indicating AL type solubility diagrams. SDs of loratadine with PEG 6...

The present study was conducted to prepare sustained release microspheres of naproxen sodium using ethyl cellulose (Ethocel 20 cps) polymer. Three different plasticizers namely polyethyleneglycol 600 (PEG 600), polyethyleneglycol 6000 (PEG 6000) and triethyl citrate (TEC) were used at 10% (wt/wt) and 40% (wt/wt) level of the drug content. Prepared microspheres were characterized with respect to...

The aerobic and anaerobic biodegradation of polyethylene glycols (PEGs) in a model wastewater was investigated employing sludge microbes from Xiamen Terylene plant. The effect of molecular weight (MW) on the aerobic/anaerobic biodegradation of PEGs was assessed by performing shake flasks/sealed flasks experiments, respectively, using organic model wastewater containing PEG 600, 6000 and 20,000....

In this paper, we studied polyetheneglycol (PEG) pretreatment effect on the mature embryo culture in vitro by using barley (Hordeum vulgare L.) seeds. Meanwhile, we analyzed and assayed its mineral element and endogenous hormone level. The experimental results were as follows: (1) PEG-6000 imbibition could obviously slow down the water timecourse absorbed by barley seeds; (2) 10% PEG-6000 treat...

drought is one of the most important abiotic stresses affecting plant growth and development. in the present study, the changes in lipid peroxidation rate and antioxidant enzyme activities were determined at different concentrations of polyethylene glycol (peg) 6000 (0, 5, 10, and 15% (w/v)) for two canola cultivars (slm046 and hyola 308). in order to produce water deficit, 12 days old canola s...

Some drugs have low bioavailability due to their poor aqueous solubility and/or slow dissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that is structurally unrelated to the currently available antiepileptics. It has poor aqueous solubility and its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) is commonly utilized as a hydroph...

Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...