A total heart-cut LC-LC-MS technique is described for the analysis of pharmaceutical compounds. Utilizing ordinary LC-MS equipment, a standardized multi-dimensional, highly selective approach was developed. The system was developed on synthetic mixtures containing ten active pharmaceutical compounds. The methodology would be further deployed for the impurity characterization of batches of activ...

BACKGROUND The use of combination antiretroviral therapy (cART) has substantially improved the outlook for patients with HIV infection. However, lifelong exposure to cART is also associated with adverse metabolic changes and an enhanced risk of renal, hepatic, and cardiovascular dysfunction. This study investigated disruptions of the urinary metabolome of cART-exposed patients, thereby furtheri...

Among non-oil exports and in trade arena, drug has always been strategic importance and most government especially industrialized countries pay special attention to its production and trade issues. Thus, having a comprehensive view from economic perspective to this section is essential for suggesting intervention. This was a descriptive-analytical and panel study. In this study, gravity model i...

BACKGROUND Poor adherence to insulin medications leads to a high rate of hospital admissions and poor health-related quality of life in the patients with diabetes mellitus. However, few strategies are effective and acceptable in improving medication adherence. The objectives of this study are to evaluate the effectiveness of pharmaceutical care by clinical pharmacists on medication adherence of...

continue to challenge the pharmaceutical industry. While pharmaceutical ventures remain productive1, rising expenditures have precipitated an increasing number of mergers and business acquisitions by the larger pharmaceutical companies. The number of such agreements in the pharmaceutical industry increased from 24 in 2003 to 45 in 20042. External factors, including a demanding regulatory enviro...

Objectives: To describe indicators and processes developed and implemented for pharmaceutical assistance at the Einstein Program at Paraisópolis Community pharmacy. Methods: This was a descriptive study of retrospective data from January 2012 to December 2015. Data were obtained from spreadsheets developed for monitoring the productivity and care quality provided at the pharmacy. The evaluate...

CONTEXT It is not known whether patient outcomes are enhanced by effective pharmacist-patient interactions. OBJECTIVE To assess the effectiveness of a pharmaceutical care program for patients with asthma or chronic obstructive pulmonary disease (COPD). DESIGN, SETTING, AND PARTICIPANTS Randomized controlled trial conducted at 36 community drugstores in Indianapolis, Ind. We enrolled 1113 pa...

BACKGROUND An Ebola outbreak of unparalleled size is currently affecting several countries in West Africa, and international efforts to control the outbreak are underway. However, the efficacy of these interventions, and their likely impact on an Ebola epidemic of this size, is unknown. Forecasting and simulation of these interventions may inform public health efforts. METHODS We use existing...

results before the intervention, there were no significant differences between mothers in two groups (p > 0.05). after 8 weeks follow up, a significant improvement appeared in mothers’ sleep quality in the intervention group. aromatherapy increased sleep quality mean score (±sd) from 8.2911 (± 2.1192) to 6.7975 (± 2.3663) (p < 0.05), but in the control group sleep quality mean score (±sd) chang...