the present report aimed to study an uncommon case of a pair of twins that presented a discordant dental phenotype. family investigation, clinical, radiographic examination and molecular analysis were performed in both girls. molecular analysis confirmed the monozygosity by deoxyribonucleic acid chip technology. one twin presented tooth agenesis in left upper lateral incisor and peg-shaped on t...

total protein and dna extracted from histologically diagnosed normal nonmalignant and esophageal tumor tissues were used for analysis of polypeptides pattern by two-dimensional gel electrophoresis and dna transforming activity in nih 3t3 cell transfection assay, respectively. in comparison to normal tissues, eight polypeptides underwent down-regulation or disappeared, while seven polypeptides w...

Wolfram syndrome is a neurodegenerative disorder caused by pathogenic variants in the genes WFS1 or CISD2. Clinically, classic phenotype composed of optic atrophy, diabetes mellitus type 1, insipidus, and deafness. syndrome, however, phenotypically heterogenous with variable clinical manifestations age onset. We describe four cases genetically confirmed presentations, including acute-on-chronic...

Langerhans cell neoplasms, which include histiocytosis and sarcoma, are tumors that originate from dendritic cells. sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features the cell-like phenotype, generally has poorer prognosis more aggressive phenotype than histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) an oncofetal...

Background: The most frequent cancer of the childhood is acute lymphoblastic leukaemia (ALL). It blood and bone marrow affecting white cells. caused by errors in DNA Our goal was to evaluate prevalence ALL Kashmiri populace. Methods: study hindsight initiated for patients registered between early 2018up late 2019 investigate its frequency prevalence. Results: Overall from 74 patients, based on ...

Salt sensitivity defines a state characterized by highly reactive blood pressure to changes in salt intake. The salt-sensitive phenotype is strongly associated with hypertension, visceral adiposity/metabolic syndrome, and ageing. Obesity accounts for around 70% of hypertension young adults, 30% 50% adult hypertensives carry the phenotype. It estimated that responsible high over 600 million adul...