Teucrium polium is used for treatment of visceral pain in Iranian folkloric medicine. In this studyantinociceptive mechanisms of T. polium hydroethanolic extract were examined by acetic acid-inducedwrithing test as a model of visceral pain in male NMRI mice. To reveal the antinociceptive mechanisms ofthe extract, we examined the effects of opioidergic, serotonergic, adrenergic and histaminergic...

Cellular Signal Integration Group, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark * Corresponding author. Cellular Signal Integration Group, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Building 301, Lyngby DK-2800, Denmark. Tel.: þ 45 2365 1941; Fax.: þ 45 4525 ...

BACKGROUND/AIMS Renalase is a recently discovered, kidney-specific monoamine oxidase that metabolizes circulating catecholamines. These findings present new insights into hypertension and chronic kidney diseases. Previous data demonstrated that renalase was mainly secreted from proximal tubules which could be evoked by catecholamines. The purpose of this study is to investigate whether renalase...

Phenylephrine exerted a positive chronotropic and inotropic effect on isolated, spontaneously beating, atria of reserpinised rabbits. Addition of phenoxybenzamine and phentolamine resulted in a depression of control contractile amplitude. Practolol, however, was devoid of this effect. The positive inotropic response to phenylephrine was significantly antagonised by all the three blockers used, ...

To study the mechanism by which norepinephrine acts on vascular muscle cell membrane, we recorded membrane potential with intracellular microelectrodes in isolated cat basilar and pial arteries. On addition of norepinephrine concentrations less than 1 microM, pial arteries hyperpolarized and relaxed while basilar arteries depolarized and contracted. Relaxation and hyperpolarization of the pial ...

Paroxysmal hypertension after cardiac surgery is a phenomenon of physiological and clinical significance. The possible preoperative and intraoperative factors that may predict its occurrence were studied in 81 consecutive patients undergoing coronary artery surgery (n = 58) or valve replacement (n = 27), of whom 45 (56%) developed postoperative hypertension. Hypertension occurred significantly ...

1. Responses of muscle strips from the stomach of the guinea-pig have been recorded. Sympathomimetic amines cause inhibitory, motor or biphasic responses.2. The motor components of the responses of the preparations were greatly enhanced by the removal of the mucosal layers.3. The inhibitory responses to isoprenaline, noradrenaline and phenylephrine were antagonized by propranolol or by sotalol....

Since the first description in the early 1990s, the scope of intravenous infusions tests has expanded to encompass multiple drug classes and indications. Purported advantages of these tests include elucidating mechanisms of pain, providing temporary relief of symptoms, and usefulness as prognostic tools in guiding drug therapy. In an attempt to discern the value of these tests, the authors cond...

Intracavernosal injection of papaverine and phentolamine was used in 20 patients with impotence. After six months 14 patients were still using the self-injection treatment. Two patients failed to respond and two patients developed priapism which responded to venesection and metaraminol injection.

Intracranial pressure (ICP) is one of most important factors in determining health and function of cerebroscular system. However the methods of measuring ICP are usually invasive . In an attempt to find a noninvasive method to assess ICP, in previous study web found a reverse relationships between changes in ICP and blood flow in scalp (SBF) and leg skin (LSBF) . In this study the role of sympa...