Nomifensine, an antidepressant agent, competitively inhibits dopamine uptake in the caudate-putamen and nucleus accumbens and binds to both dopaminergic and noradrenergic reuptake sites in the striatum and thalamus. In this study the effect of nomifensine on anacoccygeus contraction induced by noradrenaline and electrical stimulation was investigated in rats and compared to the effect of phen...

Phentolamine mesylate accelerates recovery from oral soft tissue anesthesia in patients who have received local anesthetic injections containing a vasoconstrictor. The proposed mechanism is that phentolamine, an alpha-adrenergic antagonist, blocks the vasoconstriction associated with the epinephrine used in dental anesthetic formulations, thus enhancing the systemic absorption of the local anes...

Twelve patients with stable angina pectoris received a placebo for 7 days and then oral phentolamine for an additional 7 days. Exercise was performed at the conclusion of the 2 drug periods. All of the patients developed angina with the stress of exercise while taking placebos. The average time to develop angina was 208sec. In comparison, 9 of the 12 patients were able to exercise longer after ...

The aim of this study was to examine the effects of phentolamine on severe hand, foot and mouth disease (HFMD) combined with pulmonary edema (PE). From May 2008 to December 2012, 53 children with severe HFMD plus PE were enrolled in the treatment group, receiving phentolamine intravenously at a loading dose of 5 µg/kg/min. The control group comprised 52 children with the same disease who did no...

5. Dushane JW, Kirklin JW: Late results of the repair of ventricular septal defect on pulmonary vascular disease. In Advances in Cardiovascular Surgery, edited by Kirklin JW: New York, Grune and Stratton, 1973, p 9 6. Jarmakani MM, Graham TP Jr, Canent RV Jr., Spach MS, Capp MP: Effect of site of shunt on left heart volume characteristics in children with ventricular septal defect and patent du...