BACKGROUND We examined the clinical significance of pregnancies complicated by velamentous cord insertion (VCI) associated with other umbilical cord/placental abnormalities. METHODS Data were collected from 168 deliveries complicated by VCI and from 16,797 unaffected controls. All placentae were screened identically by trained staff. In this study, we examined the presence of excessively long...

Broken cell preparations of rat and human placentas contain an inner (tyrosyl)-ring iodothyronine deiodinase enzyme with greatest activity when the substrate is 3,5,3'-triiodothyronine (T3). This report describes the deiodination of T3 in the intact placenta and the effect of sodium iopanoate (IA) and propylthiouracil (PTU) on T3 deiodination. Under nembutal anesthesia, the placenta of 60-65-d-...

PURPOSE The antipsychotic drug haloperidol can be metabolised to pyridinium metabolites haloperidol pyridinium (HP+) and reduced haloperidol pyridinium (RHP+). These pyridinium metabolites were proposed to contribute to the extrapyramidal side effects of haloperidol, because they are structural analogues of N-methyl-4-phenylpyridinium (MPP+), a well-known neurotoxin. RHP+ can be oxidized to HP+...

Fifty years ago, placenta accreta was an obstetric rarity. Today, however, placenta accreta and its variations represent one of the principal causes of maternal morbidity and mortality. That this is the case is often attributed to the increased number of cesarean deliveries, but close examination of the numbers involved suggests that other factors may also be in operation. The potential for the...

BACKGROUND Morbidly adherent placenta (MAP) with its variants is one of the most feared complications causing high morbidity and mortality in obstetrics. The objective of this study was to analyse different management options and maternal outcome in diagnosed cases of morbidly adherent placenta. METHODS Descriptive case series was carried out in Obstetrics and Gynaecology Department, Combined...

Thyroid hormones (THs) are essential for normal fetal development, with even mild perturbation in maternal thyroid status in early pregnancy being associated with neurodevelopmental delay in children. Transplacental transfer of maternal THs is critical, with increasing evidence suggesting a role for 3,3',5-tri-iodothyronine (T3) in development and function of the placenta itself, as well as in ...

Evidence for the endocrine r81e of the human placenta has been indicat’ed by manifold physiological experiments; the supporting data for this concept have been reviewed by Newton (1). Lipide extracts of human placenta have been shown to contain progestational activity as determined by the rabbit assay method (2-4). Since the progestational hormone has not been isolated from the placental extrac...