Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production stable monodisperse polyethyleneimine (PEI) polyethylene glycol (PEG) coated gold (AuNP20 AuNP50), investigation their in vivo biochemical effects BALB/c mice. Methods: were synthesized surfaces modified by PEI PEG. All necessary...

Background: Therapeutic and diagnosis properties of radioactive gold nanoparticle (198-AuNPs) cause them to be suitable for detection and treatment of tumors.Objective: Electrical and optical properties of PEG-198AuNPs were examined in this paper. Polyethylene Glycol (PEG)-198 AuNPs can be used for treatment and diagnosis of small intestine tumors.Methods: Wireless fluorescence capsule endoscop...

Nanoparticles (NPs) are widely used in various fields of nanomedicine. A systematic understanding of NP pharmacokinetics is crucial in their design, applications, and risk assessment. In order to integrate available experimental information and to gain insights into NP pharmacokinetics, a membrane-limited physiologically based pharmacokinetic (PBPK) model for polyethylene glycol-coated gold (Au...

Nontoxic nanoparticle contrast agents with multiple imaging functions are required for medical diagnostic imaging, and coating the less toxic materials meets this requirement. This work proposes a method fabricating magnetite, gold (Au), silica nanoparticles toward imaging. The proposed involved four steps: synthesis of magnetite (Fe3O4) nanoparticles, Au formation composite Fe3O4 (Fe3O4/Au), F...

The preclinical development of peptidyl drugs for cancer treatment is hampered by their poor pharmacologic properties and cell penetrative capabilities in vivo. In this study, we report a nanoparticle-based formulation that overcomes these limitations, illustrating their utility in studies of the anticancer peptide NuBCP-9, which converts BCL-2 from a cell protector to a cell killer. NuBCP-9 wa...

We report the formulation of novel composite nanoparticles that combine the high transfection efficiency of cationic peptide-DNA nanoparticles with the biocompatibility and prolonged delivery of polylactic acid-polyethylene glycol (PLA-PEG). The cationic cell-penetrating peptide RALA was used to condense DNA into nanoparticles that were encapsulated within a range of PLA-PEG copolymers. The com...

Magnetic poly (D,L-lactide-co-glycolide) (PLGA)/lipid nanoparticles (MPLs) were fabricated from PLGA, L-α-phosphatidylethanolamine (DOPE), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino (polyethylene glycol) (DSPE-PEG-NH2), and magnetic nanoparticles (NPs), and then conjugated to trans-activating transcriptor (TAT) peptide. The TAT-MPLs were designed to target the brain by magnetic gui...

BACKGROUND Therapeutic and diagnosis properties of radioactive gold nanoparticle (198-AuNPs) cause them to be suitable for detection and treatment of tumors. OBJECTIVE Electrical and optical properties of PEG-198AuNPs were examined in this paper. Polyethylene Glycol (PEG)-198 AuNPs can be used for treatment and diagnosis of small intestine tumors. METHODS Wireless fluorescence capsule endos...

The Fe3O4@C core-shell magnetic nanoparticles with an average size of about 190 nm were synthesized via a one-pot solvothermal process using ferrocene as a single reactant. The sulfonic acid-functionalized Fe3O4@C magnetic nanoparticles were obtained by grafting the sulfonic groups on the surface of Fe3O4@C nanoparticles to produce magnetically recyclable solid acid catalysts. The as-prepared p...